[Changes in renal function parameters after cotrimoxazole therapy].

John Michael Hoppe, Martin Klaus, Matthias Auer, Markus Wörnle

Abstract readCase ReportsEnglish Abstract

In one paragraph

Article in Innere Medizin (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

John Michael HoppeZentrale Notaufnahme Klinikum Innenstadt, LMU Klinikum, Ludwig-Maximilians-Universität München, Ziemssenstraße 5, 80336, München, Deutschland.

Martin KlausMedizinische Klinik und Poliklinik IV, LMU Klinikum, Ludwig-Maximilians-Universität München, München, Deutschland.

Matthias AuerZentrale Notaufnahme Klinikum Innenstadt, LMU Klinikum, Ludwig-Maximilians-Universität München, Ziemssenstraße 5, 80336, München, Deutschland.

Markus WörnleZentrale Notaufnahme Klinikum Innenstadt, LMU Klinikum, Ludwig-Maximilians-Universität München, Ziemssenstraße 5, 80336, München, Deutschland. Markus.Woernle@med.uni-muenchen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cotrimoxazole is a combination antibiotic composed of the two active substances trimethoprim and sulfamethoxazole (TMP-SMX). TMP-SMX is known to affect renal function parameters. It can cause true acute kidney injury but may also mimic acute kidney injury by inhibiting the renal secretion of creatinine. The present case demonstrates a significant increase in creatinine and urea levels, along with a reduced glomerular filtration rate, while cystatin C levels remained unchanged, representing an extent of alteration not previously reported in this form.

Indexed as

Acute Kidney InjuryAnti-Bacterial AgentsKidneyTrimethoprim, Sulfamethoxazole Drug CombinationCreatinineCystatin CFemaleGlomerular Filtration RateHumansKidney Function TestsMaleMiddle AgedUreaAnti-Bacterial AgentsCreatinineCystatin CTrimethoprim, Sulfamethoxazole Drug CombinationUreaAcute kidney injuryCreatinineCystatin CGlomerular filtration rateTrimethoprim/sulfamethoxazole

Identifiers

PMID40848061

DOI10.1007/s00108-025-01974-6

PMCPMC12647179

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.