ArticleOral and maxillofacial surgery2025
The synergetic potential of gold nanoparticles and bone marrow stem cells in regeneration of tongue defects (An experimental study on Rats).
Article in Oral and maxillofacial surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Plant Exosome Injection: A New Boost for Postlaser Vascular Repair.The Journal of clinical and aesthetic dermatology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe tongue plays a vital role in physiological functions where tissue loss impairs the patient's life, so regenerative approaches are crucial. This study was performed to explore the synergetic possibility of gold nanoparticles (AuNPs) and bone marrow stem cells (BMSCs) in tongue defect regeneration.
methodsRats were subjected to surgical defects on the tongue's dorsal surface and divided into four groups: Group I (control): received no treatment, Group II (AuNPs): received 0.1 ml AuNPs solution (50 nm diameter) 1 mm sub-epithelial, Group III (BMSCs): received 0.1 ml BMSCs (3.5 × 105 cells/cm2), and Group IV (BMSCs/AuNPs) received 0.1 ml BMSCs (3.5 × 105 cells/cm2) previously cultured with 6 µg/ml AuNPs. Circumferential injections were made around the defect. Samples were collected and prepared for histological and immunohistochemical staining four and seven days after treatment, and then histomorphometric and statistical analyses were performed.
resultsThe BMSCs/AuNPs group revealed better histological regeneration, including consistent epithelial stratification with a thick keratin layer, a regularly arranged basal cell layer, more vascularity, and well-arranged muscle bundles in connective tissue with fewer inflammatory cells than other groups. Regarding immunohistochemical. results, the BMSCs/AuNPs group demonstrated a significant increase in PCNA and S100 expression in both time intervals in comparison with other groups.
conclusionsWound healing after AuNPs in conjugation with BMSCs emphasized their synergetic effect on BMSCs. Attained. results extend to applied nanotechnology and regenerative medicine, supporting the application of AuNPs in wound healing fields.
Indexed as
Identifiers
40848060What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.