Evidence map›Paper›PMID 40848030›Full record

Trial reportThe journal of allergy and clinical immunology. In practice2025

A Pilot Pragmatic Cluster Randomized Trial of School-Supervised Therapy to Improve Pediatric Asthma Control.

Michelle Trivedi, Michelle Spano, Christine Frisard, Sybil Crawford, Grace Ryan, Melissa Goulding, Sonia Radu, Juliana Arenas, Sarah Becker, Layana Al-Halbouni and 7 more

Abstract readRandomized Controlled TrialPragmatic Clinical Trial
In one paragraph

Trial report in The journal of allergy and clinical immunology. In practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Clinician and family perspectives on the use of single maintenance and reliever therapy for children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Michelle TrivediDivision of Pulmonary Medicine, Department of Pediatrics, UMass Chan Medical School, UMass Memorial Children's Medical Center, Worcester, Mass; Department of Population and Quantitative Health Sciences, UMass Chan Medical School, Worcester, Mass; Child Health Equity Center, Department of Pediatrics, UMass Chan Medical School, UMass Memorial Children's Medical Center, Worcester, Mass. Electronic address: michelle.trivedi3@umassmed.edu.
Michelle SpanoDivision of Pulmonary Medicine, Department of Pediatrics, UMass Chan Medical School, UMass Memorial Children's Medical Center, Worcester, Mass.
Christine FrisardDepartment of Population and Quantitative Health Sciences, UMass Chan Medical School, Worcester, Mass.
Sybil CrawfordTan Chingfen Graduate School of Nursing, UMass Chan Medical School, Worcester, Mass.
Grace RyanDepartment of Population and Quantitative Health Sciences, UMass Chan Medical School, Worcester, Mass.
Melissa GouldingDepartment of Population and Quantitative Health Sciences, UMass Chan Medical School, Worcester, Mass.
Sonia RaduDivision of Pulmonary Medicine, Department of Pediatrics, UMass Chan Medical School, UMass Memorial Children's Medical Center, Worcester, Mass.
Juliana ArenasDepartment of Pediatrics, Brown University, Providence, RI.
Sarah BeckerDivision of Pulmonary Medicine, Department of Pediatrics, UMass Chan Medical School, UMass Memorial Children's Medical Center, Worcester, Mass.
Layana Al-HalbouniDivision of Pulmonary Medicine, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn.
Jordan AlterDepartment of Pediatrics, Yale New Haven Medical Center, New Haven, Conn.
Nancy ByattDepartment of Population and Quantitative Health Sciences, UMass Chan Medical School, Worcester, Mass; Lifeline for Families Center, Department of Psychiatry, UMass Chan School of Medicine, Worcester, Mass; Department of Obstetrics and Gynecology, UMass Chan Medical School, Worcester, Mass.
Wanda PhipatanakulDivision of Asthma, Allergy, and Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Milagros C RosalDepartment of Population and Quantitative Health Sciences, UMass Chan Medical School, Worcester, Mass.
Stephenie C LemonDepartment of Population and Quantitative Health Sciences, UMass Chan Medical School, Worcester, Mass.
Lynn B GeraldOffice of Population Health Sciences, University of Illinois, Chicago, Ill.
Lori PbertDepartment of Population and Quantitative Health Sciences, UMass Chan Medical School, Worcester, Mass.

Funding

Asthma Link: A Partnership between Pediatric Practices, Schools, and Families to Improve Medication Adherence and Health Outcomes in Children with Poorly Controlled AsthmaR01HL169229 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Michelle Trivedi · 2023 to 2026
$3.0M
Asthma Link: School Supervised Therapy to Improve Medication Adherence in Children with Poorly Controlled AsthmaK23HL150341 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI TRIVEDI, MICHELLE · 2020 to 2024
$881k
NHLBI NIH HHS K23 HL150341NHLBI NIH HHS R01 HL169229
6 · The paper itself

Abstract

backgroundAlthough school-supervised inhaled corticosteroid administration has potential to improve asthma morbidity, there has yet to be an evaluation of the pediatric practice as a setting to identify children with asthma and connect them to school-supervised asthma therapy.

objectiveConduct a pragmatic pilot trial of Asthma Link, a model that connects children with asthma seen in pediatric practice to supervised asthma therapy in the school setting.

methodsFour pediatric practices were pair-matched and randomized to (1) Asthma Link plus an asthma educational workbook or (2) Enhanced Usual Care, the same workbook alone. We recruited children 6 to 17 years old with poorly controlled asthma, prescribed a daily inhaled corticosteroid. Parent-child dyads completed surveys at baseline and 3, 6, and 12 months. PRIMARY OUTCOMES: recruitment/retention of pediatric practices and parent-child dyads and intervention fidelity. SECONDARY OUTCOMES: asthma symptoms, medication adherence, emergency room visits, hospital admissions, oral steroid use, missed schooldays.

resultsFour pediatric practices and 66 parent-child dyads were recruited (average child age 9 y, 44% female, 65% Hispanic, 23% Black, 62% low income). All (4 of 4) practices were retained throughout the study and retention of parent-child dyads was 95%, 91%, and 89% at 3, 6, and 12 months, respectively. All (31 of 31) Asthma Link families brought their child's preventive inhaler into school; children received school health staff-supervised therapy on more than 95% of schooldays over 12 months. Children in the Asthma Link group had greater improvement in Asthma Control Test scores, longer time to first asthma exacerbation, less oral steroid use, and better medication adherence compared with the Enhanced Usual Care group.

conclusionsExtending the reach of pediatric practices to facilitate the delivery of daily asthma prevention medication at school was feasible and improved pediatric asthma morbidity.

Indexed as

Adrenal Cortex HormonesAnti-Asthmatic AgentsAsthmaSchool Health ServicesAdministration, InhalationAdolescentChildFemaleHumansMaleMedication AdherenceParentsPatient Education as TopicPilot ProjectsSchoolsAdrenal Cortex HormonesAnti-Asthmatic AgentsAsthmaClinicalCluster randomized trialCommunity-clinical linkageCommunity trialPediatricPracticeSchoolSustainable

Identifiers

PMID40848030
PMCPMC12380124

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.