Dehydroepiandrosterone Decline in Aging Males as a Predictor of Erectile Dysfunction and Mood Disorders in Patients With Benign Prostate Hyperplasia Undergoing Dutasteride Treatment.

Maja Sofronievska Glavinov, Senol Tahir, Stefan Arsov

Abstract read

In one paragraph

Article in American journal of men's health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Maja Sofronievska GlavinovFaculty of Medical Sciences, Goce Delcev University, Stip, North Macedonia Urology Department, University Surgery Hospital St.Naum Ohridski, Skopje, North Macedonia.ORCID 0000-0002-7857-6056

Senol TahirFaculty of Medical Sciences, Goce Delcev University, Stip, North Macedonia Visceral Surgery Department, University Surgery Hospital St.Naum Ohridski, Skopje, North Macedonia.

Stefan ArsovFaculty of Medical Sciences, Goce Delcev University, Stip, North Macedonia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related decline in dehydroepiandrosterone (DHEA) and its sulfate metabolite, dehydroepiandrosterone-sulfate (DHEAS), affects steroid synthesis in men. DHEA(S) acts as a direct neurosteroid and weak androgen and is the unique steroid unaffected by dutasteride's inhibitory effect on 5α reductases. This study examined the relationship between dutasteride's side effects, specifically erectile dysfunction (ED) and mood disorders, and the age-related decline in DHEAS. The study included 250 patients with benign prostatic hyperplasia (BPH), divided into two age groups (<60 and ≥60 years), and treated with tamsulosin or tamsulosin plus dutasteride. DHEAS levels were measured, and patients were assessed for ED and mood disorders using standardized questionnaires. Some patients experienced worsening ED and mood disorders during the 6-month follow-up period. The study found a correlation between DHEAS levels and erectile function and mood status in both age groups receiving dutasteride combination therapy (

Indexed as

5-alpha Reductase InhibitorsAgingDehydroepiandrosteroneDutasterideErectile DysfunctionMood DisordersProstatic HyperplasiaAgedHumansMaleMiddle AgedTamsulosin5-alpha Reductase InhibitorsDehydroepiandrosteroneDutasterideTamsulosinbenign prostate hyperplasiadehydroepiandrosteronedutasterideerectile dysfunctionmood disorders

Identifiers

PMID40847811

DOI10.1177/15579883251365091

PMCPMC12375160

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LicenceCC BY-NC

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.