ArticleJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2025
Low-dose total skin electron beam therapy in erythrodermic mycosis fungoides and Sézary syndrome: Results From the Prospective S-MISR Study.
Article in Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Modern approaches to radiotherapy in primary cutaneous lymphomas: insights and recommendations from the DEGRO dermato-oncology working group.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Guideline
- Low-dose total skin electron beam therapy in erythrodermic mycosis fungoides and Sézary syndrome: Results From the Prospective S-MISR Study.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundErythrodermic mycosis fungoides (eMF) and Sézary syndrome (SS) often show delayed and non-durable clinical responses to systemic therapies. PATIENTS AND
methodsA total of 35 patients with eMF or SS were treated with total skin electron beam therapy (TSEBT). Response rates, patient-reported outcomes, survival data, median time to next treatment (TTNT), and progression-free survival (PFS) were evaluated.
resultsThe analysis included 21 patients with SS and 14 with eMF. The median radiation dose was 12 Gy. At 3 months post-TSEBT, the overall response rate was 89%. A total of 25 patients (71%) required subsequent systemic therapy. The median TTNT was 20 months, and the median PFS was 14 months. Patients reported marked reductions in pruritus, decreased skin disease burden, and improved health-related quality of life scores. Notably, both TTNT and PFS were longer in patients who received subsequent therapy compared to those who did not. Grade ≥3 radiation-related toxicity was observed in 6% of patients. In the translational arm of the study, several potential peripheral blood biomarkers were identified.
conclusionsLow-dose TSEBT is an effective treatment option for patients with eMF and SS, facilitating subsequent therapies and enabling long-term disease control. The treatment is associated with significant quality-of-life improvements and low toxicity.
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