ArticleLiver international : official journal of the International Association for the Study of the Liver2025
Assessment of PBC Pruritus From the ITCH-E Study: Quality of Life, Productivity, and Treatment Experiences.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Psychometric evaluation of PROMISQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Review
- Assessment of PBC Pruritus From the ITCH-E Study: Quality of Life, Productivity, and Treatment Experiences.Liver international : official journal of the International Association for the Study of the Liver · 2025Article
- Consensus statements of the Hellenic Autoimmune Liver Diseases Study Group on the diagnosis and current management of primary biliary cholangitis.Annals of gastroenterologyArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
BACKGROUND &
aimsThis US-based study assessed the impact of pruritus on health-related quality of life (HRQoL) and treatment experiences of people with primary biliary cholangitis (PBC).
methodsPatients with PBC were recruited from a physician panel and patient advocacy group. Participants were grouped by the Pruritus Numerical Rating Scale (NRS): No/Mild Pruritus (NMP, NRS < 4) and Moderate/Severe Pruritus (MSP, NRS ≥ 4). Participants completed the 5-D Itch, PBC-40, EQ-5D-5L, Chronic Liver Disease Questionnaire (CLDQ-PBC), Work Productivity and Activity Impairment (WPAI), and Functional Assessment of Chronic Illness Therapy - Fatigue Scale, Version 4 (FACIT-Fatigue) questionnaires, and PBC treatment experiences questions. Differences were analysed using regression models for confounders. An MSP group subset responded to voice questions.
resultsThe sample included 40 NMP and 50 MSP participants, with 85% and 80% females, respectively. The MSP group reported significantly worse outcomes on 5-D Itch, EQ-5D Index, PBC-40 (all domains besides Emotional), FACIT-Fatigue, and CLDQ-PBC total scores compared to the NMP group (all p < 0.05). The MSP group reported significantly greater activity impairment due to PBC (57%) than the NMP group (36%; p < 0.001). The MSP group had a lower employment rate (42%) than the NMP group (53%). Fewer than 25% of the MSP group were receiving itch treatment.
conclusionsIndividuals with PBC and pruritus report limited pruritus treatment use and minimal itch relief. Those with moderate/severe pruritus experience a greater HRQoL burden and reduced activity compared to those with mild/no pruritus. This highlights the need for effective treatments that ameliorate pruritus in patients with PBC.
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Registered trials
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