Evidence map›Paper›PMID 40847587›Full record

ArticleAnnals of medicine2025

Emotional stress: a prominent factor positively related to the onset and recurrence of bladder cancer as revealed by NHANES and a Chinese database.

Wentao Luo, Yifei Chen, Danjing Shen, Yiyang Zhang, Wentao Zhang, Tianyuan Xu, Haotian Chen, Xiangqian Cao, Yilin Yan, Bin Yang and 2 more

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Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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12 authors.

Wentao LuoDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yifei ChenDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Danjing ShenDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yiyang ZhangDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Wentao ZhangDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Tianyuan XuDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Haotian ChenDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiangqian CaoDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yilin YanDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Bin YangDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Wei LiDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0001-6728-1300
Bing ShenDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveBladder cancer and emotional stress are both common physiologic problems, with few published studies and a lack of studies with large samples discussing their association. The aim of this study was to investigate the association between bladder cancer and emotional stress. RESEARCH

methodsWe used data from the U.S. National Health and Nutrition Examination Survey (NHANES) database for the period 2005 to 2020 and the Bladder Cancer Database from Shanghai Tenth People's Hospital of Tongji University. The above two databases were used for two independent cross-sectional studies, respectively. We adopted the method of multivariate logistic regression to analyze the relationship between the occurrence of bladder cancer and depression, as well as the relationship between the recurrence of bladder cancer and emotional stress.

resultsBased on the NHANES database, a total of 23,801 participants were enrolled in our study, including 100 participants diagnosed with bladder cancer and 23,701 participants not diagnosed with bladder cancer. After adjustment for covariates, there was a significant positive association between bladder cancer and mild depression (OR: 2.43, 95% CI: 1.41, 4.00). There was a significant positive association between recurrence of bladder cancer and general depression (OR: 2.16, 95% CI: 1.20, 3.88) among 303 bladder cancer patients in the Chinese database.

conclusionThis study reveals a strong association between bladder cancer and emotional stress, with patients with bladder cancer having a significant risk of depression and elevated emotional stress potentially associated with bladder cancer recurrence.

Indexed as

DepressionNeoplasm Recurrence, LocalStress, PsychologicalUrinary Bladder NeoplasmsAdultAgedChinaCross-Sectional StudiesDatabases, FactualEast Asian PeopleFemaleHumansLogistic ModelsMaleMiddle AgedNutrition SurveysBladder cancercross-sectional studyemotional stressNHANES

Identifiers

PMID40847587
PMCPMC12377135

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