Evidence map›Paper›PMID 40847564›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Beyond Neuroprostanes: Total Synthesis and Epilipidomic Studies of a Novel Cyclopentenone Metabolite of Docosahexaenoic Acid.

Tereza Pavlíčková, Valérie Bultel-Poncé, Jérôme Roy, Guillaume Reversat, Claire Vigor, Thierry Durand, Ullrich Jahn, Jean-Marie Galano, Camille Oger

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tereza PavlíčkováInstitut des Biomolécules Max Mousseron, IBMM, Univ. Montpellier, CNRS, ENSCM, 1919 route de Mende, Montpellier, 34293, France.ORCID https://orcid.org/0000-0003-3161-0170
Valérie Bultel-PoncéInstitut des Biomolécules Max Mousseron, IBMM, Univ. Montpellier, CNRS, ENSCM, 1919 route de Mende, Montpellier, 34293, France.ORCID https://orcid.org/0000-0002-2153-3872
Jérôme RoyUniversite de Pau et des Pays de l'Adour, INRAE, Aquapole, NUMEA, Saint-Pee-sur-Nivelle, 64310, France.ORCID https://orcid.org/0000-0002-3007-1585
Guillaume ReversatInstitut des Biomolécules Max Mousseron, IBMM, Univ. Montpellier, CNRS, ENSCM, 1919 route de Mende, Montpellier, 34293, France.
Claire VigorInstitut des Biomolécules Max Mousseron, IBMM, Univ. Montpellier, CNRS, ENSCM, 1919 route de Mende, Montpellier, 34293, France.ORCID https://orcid.org/0000-0002-1569-0425
Thierry DurandInstitut des Biomolécules Max Mousseron, IBMM, Univ. Montpellier, CNRS, ENSCM, 1919 route de Mende, Montpellier, 34293, France.ORCID https://orcid.org/0000-0001-6086-7296
Ullrich JahnInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo náměstí 2, Prague 6, 16600, Czech Republic.ORCID https://orcid.org/0000-0001-8386-1348
Jean-Marie GalanoInstitut des Biomolécules Max Mousseron, IBMM, Univ. Montpellier, CNRS, ENSCM, 1919 route de Mende, Montpellier, 34293, France.ORCID https://orcid.org/0000-0001-6412-4967
Camille OgerInstitut des Biomolécules Max Mousseron, IBMM, Univ. Montpellier, CNRS, ENSCM, 1919 route de Mende, Montpellier, 34293, France.ORCID https://orcid.org/0000-0002-5177-5792

Funding

Gilead Sciences & IOCB Research Center GSRCIIIIOCB Prague RVO61388963
6 · The paper itself

Abstract

Neuroprostanes (NeuroPs) are bioactive oxylipins formed in vivo from docosahexaenoic acid (DHA), the main polyunsaturated fatty acid of the human brain, by a nonenzymatic auto-oxidative process as mixtures of regio- and diastereoisomers. Thus, synthetic material is necessary to unlock their potential as oxidative stress biomarkers as well as to investigate the biological properties of individual NeuroP molecules. Despite recent advances in the field, cyclopentenone-type NeuroPs have received limited attention. Here, we present an enantioselective total synthesis of 4-A

Indexed as

CyclopentanesDocosahexaenoic AcidsNeuroprostanesBrainHumansOxylipinsStereoisomerismCyclopentanescyclopentenoneDocosahexaenoic AcidsNeuroprostanesOxylipinsasymmetric synthesisbiomarkerslipidsneuroprostanestotal synthesis

Identifiers

PMID40847564
PMCPMC12520055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.