Evidence map›Paper›PMID 40847539›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Cyclochlorotine Hydroxylase CctR Reveals DUF3328 as a Family of Copper-Dependent Metalloenzymes.

Wentao Huang, Jakob K Reinhardt, Anru Tian, Xiao Zhang, Binghui Li, Noah Gould, Sashirekha Nallapati, Alexander R Ivanov, Yi Wang, Jason J Guo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Emerging classes of copper enzymes.Current opinion in chemical biology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wentao HuangInstitute for Plant-Human Interface, Northeastern University, Boston, MA, 02115, USA.
Jakob K ReinhardtInstitute for Plant-Human Interface, Northeastern University, Boston, MA, 02115, USA.
Anru TianWhitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA.
Xiao ZhangDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Binghui LiDepartment of Physics, The Chinese University of Hong Kong, Hong Kong, P. R. China.
Noah GouldDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA.
Sashirekha NallapatiDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA.
Alexander R IvanovDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA.
Yi WangDepartment of Physics, The Chinese University of Hong Kong, Hong Kong, P. R. China.
Jason J GuoDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA.
David E BudilDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA.
Jing-Ke WengInstitute for Plant-Human Interface, Northeastern University, Boston, MA, 02115, USA.ORCID 0000-0003-3059-0075

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Chan Zuckerberg InitiativeNational Institute of Food and AgricultureNCI NIH HHS P30 CA023108Schooner FoundationW. M. Keck Foundation
6 · The paper itself

Abstract

DUF3328 is a protein family widely found in fungal natural product biosynthesis pathways. Although DUF3328 proteins have long been implicated in diverse modifications of inert C(sp

Indexed as

CopperMetalloproteinsMixed Function OxygenasesPeptides, CyclicHydroxylationCopperMetalloproteinsMixed Function OxygenasesPeptides, CyclicEnzyme catalysisHydroxylaseMetalloenzymesNatural product biosynthesisNon‐ribosomal peptides

Identifiers

PMID40847539
PMCPMC12435403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.