Evidence map›Paper›PMID 40847518›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Self-Trapped Excitons in Carbon Quantum Dots with Large NIR-II Photo-Thermoelectric Catalysis Induce Pyroptosis for Cancer Therapy.

Tesen Zhang, Qingcheng Wang, Quansheng Cheng, Han Wang, He Feng, Hui Zhang, Mengbo Lin, Feili Cai, Zheng Fang, Ruo Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tesen ZhangInterdisciplinary Institute of Medical Engineering, Fuzhou University, Fuzhou, 350108, China.ORCID https://orcid.org/0000-0002-2071-7477
Qingcheng WangInstitute of Applied Physics and Materials Engineering, University of Macau, Macau, SAR, 999078, China.
Quansheng ChengInstitute of Applied Physics and Materials Engineering, University of Macau, Macau, SAR, 999078, China.
Han WangDepartment of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
He FengInstitute of Applied Physics and Materials Engineering, University of Macau, Macau, SAR, 999078, China.
Hui ZhangShengli Clinical Medical College of Fujian Medical University, Department of Breast Surgery, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, 350001, China.
Mengbo LinShengli Clinical Medical College of Fujian Medical University, Department of Breast Surgery, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, 350001, China.
Feili CaiShengli Clinical Medical College of Fujian Medical University, Department of Breast Surgery, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, 350001, China.
Zheng FangInstitute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Ruo WangShengli Clinical Medical College of Fujian Medical University, Department of Breast Surgery, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, 350001, China.
Gang ChenShengli Clinical Medical College of Fujian Medical University, Department of Endocrinology, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China.

Funding

Fujian Talent Funds (Fujian Provincial Hospital) 00801109Fujian Talent Funds (Fujian Provincial Hospital) 00802741Joint Funds for the innovation of science and Technology, Fujian province 2024Y9018National Natural Science Foundation of China 224B2406Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0531600
6 · The paper itself

Abstract

Pyroptosis, an immunogenic cell death mechanism triggered by Gasdermin family proteins, represents a transformative frontier in tumor immunotherapy. While carbon quantum dots (CQDs) have emerged as pyroptosis-triggering agents, their efficacy in NIR-II light-mediated therapy remains constrained by a low absorption coefficient and uncontrolled charge recombination. Herein, CQDs with high-density self-trapped excitons (STEs) exhibiting NIR-II absorption and an exceptional photothermal conversion efficiency of 51.2% are engineered. By optimizing the migration dynamics of hot carriers, directional charge separation is achieved, which generates cytotoxic hydroxyl radicals and superoxide radicals. The synergistic photo-thermoelectric catalysis triggers pyroptosis via reactive oxygen species-caspase 1-gasdermin D activation, eliciting robust systemic immunity that effectively eliminates the primary tumor and prevents tumor recurrence. This work establishes STE engineering as a universal design principle for advanced nanomaterials while pioneering a NIR-II-responsive pyroptosis platform that bridges localized ablation with systemic antitumor immunity, offering a paradigm shift for precision immuno-oncology.

Indexed as

CarbonNeoplasmsPyroptosisQuantum DotsAnimalsCatalysisCell Line, TumorHumansInfrared RaysMiceCarboncancer therapycarbon dotsNIR‐II photo‐thermoelectric catalysispyroptosisself‐trapped excitons

Identifiers

PMID40847518
PMCPMC12822447

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.