Evidence map›Paper›PMID 40847514›Full record

ArticleJournal of the American Heart Association2025

Effects of Pharmacological Polyploidization in Human iPSC-Derived Cardiomyocytes.

Nicholas Strash, Marisa Patsy, Sophia DeLuca, Abbigail Helfer, Xixian Jiang, Tianyu Wu, Nenad Bursac

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicholas StrashDepartment of Cell Biology Duke University Durham NC.ORCID 0000-0003-1907-0925
Marisa PatsyDepartment of Biomedical Engineering Duke University Durham NC.ORCID 0000-0001-9173-5763
Sophia DeLucaDepartment of Cell Biology Duke University Durham NC.
Abbigail HelferDepartment of Biomedical Engineering Duke University Durham NC.
Xixian JiangDepartment of Biomedical Engineering Duke University Durham NC.
Tianyu WuDepartment of Biomedical Engineering Duke University Durham NC.ORCID 0000-0002-7341-2781
Nenad BursacDepartment of Cell Biology Duke University Durham NC.ORCID 0000-0002-5688-6061

Funding

Project 3 - Role of Proline Metabolism in Regulation of Mammalian Cardiomyocyte ProliferationP01HL160476 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GREGORY P WALCOTT · 2022 to 2026
$13.1M
Training Program in Developmental & Stem Cell BiologyT32HD040372 · NICHD · DUKE UNIVERSITY · PI Terry H Lechler · 2001 to 2026
$8.9M
Integrated Cellular and Tissue Engineering for Ischemic Heart DiseaseU01HL134764 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BURSAC, NENAD, KAMP, TIMOTHY J. · 2016 to 2022
$7.7M
Engineering Human Heart Tissues with Polyploid CardiomyocytesR01HL164013 · NHLBI · DUKE UNIVERSITY · PI BURSAC, NENAD · 2022 to 2025
$2.2M
Engineered BacNav and BacCav for Improved Excitability and ContractionR01EB032726 · NIBIB · DUKE UNIVERSITY · PI BURSAC, NENAD · 2022 to 2025
$1.9M
Investigating the Role of Polyploidy in the Maturation of hiPSC-derived CardiomyocytesF31HL156453 · NHLBI · DUKE UNIVERSITY · PI STRASH, NICHOLAS A · 2021 to 2023
$105k
Investigating Mitogenic Mechanism and Therapeutic Efficacy of Adenosine Deaminase Knockout in Human and Murine CardiomyocytesF31HL162460 · NHLBI · DUKE UNIVERSITY · PI DELUCA, SOPHIA BUNNELL · 2022 to 2023
$84k
NHLBI NIH HHS F31 HL156453NHLBI NIH HHS F31 HL162460NHLBI NIH HHS P01 HL160476NHLBI NIH HHS R01 HL164013NHLBI NIH HHS U01 HL134764NIBIB NIH HHS R01 EB032726NICHD NIH HHS T32 HD040372
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

calciumcardiomyocytehypertrophypolyploidyproliferation

Identifiers

PMID40847514
PMCPMC12553442

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.