ArticleJournal of the American Heart Association2025
Inflammatory Status Modifies the Association Between Glycemic Traits and Cognitive Impairment in Patients With Coronary Artery Disease.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Advances in brain MRI for CAD-associated cognitive impairment with supplementary perspectives from traditional Chinese medicine.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe evidence regarding the modifying role of inflammation in the association between glycemic traits and cognitive impairment remains insufficient. This study aimed to explore the association between glycemic traits and mild cognitive impairment (MCI) in patients with coronary artery disease (CAD), with particular emphasis on whether this association is influenced by varying levels of inflammation.
methodsThis cross-sectional study included 1437 patients with CAD who underwent cognitive function assessment during hospitalization. Cognitive function was assessed using the Mini-Mental State Examination and the Montreal Cognitive Assessment to identify patients with MCI. The hsCRP (high-sensitivity C-reactive protein) level>3 mg/L was defined as high inflammatory risk. Multivariable logistic regression models were employed to estimate the associations of glycemic traits and inflammatory risk status with cognitive impairment.
resultsElevated fasting plasma glucose, glycosylated hemoglobin, and diabetes were positively associated with an increased risk of MCI in patients with CAD, with odds ratios ranging from 1.18 (95% CI, 1.10-1.26) to 1.55 (95% CI, 1.09-2.20). A significant interaction was observed between glycosylated hemoglobin and high inflammatory status on the risk of MCI (
conclusionsInflammatory status modifies the association between glycemic traits and the risk of cognitive impairment. This finding highlights the importance of incorporating inflammation into the management of blood glucose levels in patients with CAD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.