ArticleJournal of the American Heart Association2025
Circulating Mucosal-Associated Invariant T Cells Are Associated With Acute Human Ischemic Stroke and Predict Poor Outcome.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Multifaceted mechanisms of unconventional T cells in ischemia-reperfusion injury.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMucosal-associated invariant T (MAIT) cells are involved in acute ischemic stroke in mice models. This study aimed to clarify the dynamics and role of circulating MAIT cells in patients with acute ischemic stroke.
methodsPatients with acute ischemic stroke were classified according to the National Institutes of Health Stroke Scale into severe (score ≥ 10) and mild (score < 10) groups; outpatients with matched sex and age were selected as controls. Circulating MAIT cells, activation (CD69+), and cytokine production (IFN-γ [interferon-gamma] + and IL-17 [interleukin-17]+) on days 3, 10, and 17 after stroke, along with invariant natural killer T cells, gamma delta T cells, CD4+, and CD8+ T-cell populations, were analyzed by flow cytometry. The relationship between MAIT cell dynamics and clinical outcomes was examined.
resultsOne hundred participants (30 severe, 40 mild, 30 controls) were included. On day 3, patients with severe stroke had a significantly lower proportion of MAIT cells than the mild group and controls (severe, mild, control [median]: 0.09%, 0.33%, 0.38%, respectively;
conclusionsAn early decrease in MAIT cells with higher activity and proinflammatory cytokine production correlated with stroke severity and poor outcomes, suggesting a significant role of MAIT cells in acute cerebral infarction and unfavorable outcomes.
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