Evidence map›Paper›PMID 40847480›Full record

ArticleJournal of the American Heart Association2025

Adenosine A

Xiangxiang Lin, Weishan ZhuGe, Wu Zheng, Xia Liu, Huiping Shang, Jianhong Zhou, Manli Jia, Yuanyuan Ge, Wenqi Qian, Liuqing Gu and 6 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xiangxiang LinZhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Department of Neurosurgery The First Affiliated Hospital of Wenzhou Medical University Wenzhou China.ORCID 0000-0003-2912-0877
Weishan ZhuGeSchool of Pharmaceutical Sciences Wenzhou Medical University Wenzhou China.ORCID 0009-0000-5535-5325
Wu ZhengDepartment of Neurology, Ningbo Medical Center Li Huili Hospital The Affiliated Li Huili Hospital, Ningbo University Ningbo City China.ORCID 0000-0002-5091-9694
Xia LiuDepartment of Anesthesiology The First Affiliated Hospital of Ningbo University Ningbo Zhejiang China.
Huiping ShangState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital Wenzhou Medical University Wenzhou China.
Jianhong ZhouState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital Wenzhou Medical University Wenzhou China.
Manli JiaState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital Wenzhou Medical University Wenzhou China.
Yuanyuan GeState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital Wenzhou Medical University Wenzhou China.
Wenqi QianZhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Department of Neurosurgery The First Affiliated Hospital of Wenzhou Medical University Wenzhou China.ORCID 0000-0003-0928-1542
Liuqing GuZhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Department of Neurosurgery The First Affiliated Hospital of Wenzhou Medical University Wenzhou China.ORCID 0009-0008-3783-6609
Yan HeState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital Wenzhou Medical University Wenzhou China.
Xiao LinZhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Department of Neurosurgery The First Affiliated Hospital of Wenzhou Medical University Wenzhou China.ORCID 0000-0001-9095-3187
Kunlin JinDepartment of Pharmacology and Neuroscience University of North Texas Health Science Center Fort Worth TX USA.ORCID 0000-0002-1336-348X
Xiaokun LiSchool of Pharmaceutical Sciences Wenzhou Medical University Wenzhou China.ORCID 0009-0003-3908-6905
Qichuan ZhuGeZhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Department of Neurosurgery The First Affiliated Hospital of Wenzhou Medical University Wenzhou China.ORCID 0000-0002-2427-1927
Jiangfan ChenState Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital Wenzhou Medical University Wenzhou China.ORCID 0000-0002-0446-3956

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStroke remains a leading cause of death and disability worldwide, but the therapeutic efficacies of the mainstay treatments, mechanical thrombectomy and intravenous thrombolysis, are limited due to constraints such as the narrow treatment window and the issue of reperfusion injury following restoration of blood flow. Ischemia-reperfusion (I/R) injury is characterized by the infiltration of peripheral leukocytes, which are believed to enter the central nervous system through the breakdown of the blood-brain barrier. However, the involvement of the choroid plexus (ChP), a part of the blood-cerebrospinal fluid barrier, in development of I/R injury is often overlooked. The adenosine A METHODS AND

resultsWe investigated ChP A

conclusionsOur findings highlight the A

Indexed as

Cerebral CortexChoroid PlexusReceptor, Adenosine A2AReperfusion InjuryAdenosine A2 Receptor AntagonistsAnimalsApoptosisBlood-Brain BarrierDisease Models, AnimalMaleMiceMice, Inbred C57BLNeutrophil InfiltrationNeutrophilsAdenosine A2 Receptor AntagonistsReceptor, Adenosine A2Aadenosine A2A receptorchoroid plexusimmune infiltrationischemia–reperfusion injury

Identifiers

PMID40847480
PMCPMC12553465

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.