Evidence map›Paper›PMID 40847455›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Citrullination of AKT2 Catalyzed by PAD1 Facilitates the Maintenance of Stemness Characteristics of Ovarian Cancer Stem-Like Cells in Ovarian Cancer.

Teng Xue, Xiaoqiu Liu, Chao Song, Shujia Fei, Jian Gu, Yun Han, Jia Xing, Xiaohan Liu, Fei Liang, Paul R Thompson and 1 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Teng XueDepartment of Histology and Embryology, College of Basic Medical Science, China Medical University, Shenyang, 110122, China.
Xiaoqiu LiuDepartment of Pathology, College of Basic Medical Science, China Medical University, Shenyang, 110122, China.
Chao SongState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China.
Shujia FeiState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China.
Jian GuState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China.
Yun HanDepartment of Obstetrics and Gynecology, Affiliated Hospital 2 of Nantong University and Nantong First People's Hospital, Nantong, Jiangsu, 226001, China.
Jia XingDepartment of Histology and Embryology, College of Basic Medical Science, China Medical University, Shenyang, 110122, China.
Xiaohan LiuDepartment of Histology and Embryology, College of Basic Medical Science, China Medical University, Shenyang, 110122, China.
Fei LiangDepartment of Histology and Embryology, College of Basic Medical Science, China Medical University, Shenyang, 110122, China.
Paul R ThompsonDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, 01655, USA.
Xuesen ZhangDepartment of Histology and Embryology, College of Basic Medical Science, China Medical University, Shenyang, 110122, China.ORCID 0000-0001-8877-1536

Funding

Department of Science and Technology of Liaoning Province 2023JH2/20200002Nantong Health Commission Research Project MS2024022National Natural Science Foundation of China 82172945National Natural Science Foundation of China 82203869
6 · The paper itself

Abstract

The presence of ovarian cancer stem-like cells (OCSLCs) is a crucial driving force for malignant progression, metastasis, and tumor recurrence of ovarian cancer (OC). However, the mechanisms underlying activation and maintenance of OCSLC stemness remain unclear. Here, it is identified an increased expression of peptidylarginine deiminase 1 (PAD1) in OC cells, particularly within the CD133

Indexed as

CitrullinationNeoplastic Stem CellsOvarian NeoplasmsProtein-Arginine DeiminasesProto-Oncogene Proteins c-aktAnimalsCell Line, TumorCisplatinDrug Resistance, NeoplasmFemaleHumansMiceAKT2 protein, humanCisplatinProtein-Arginine DeiminasesProto-Oncogene Proteins c-aktAKT2citrullinationovarian cancer stem‐like cellsPAD1stemness maintenance

Identifiers

PMID40847455
PMCPMC12533369

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.