ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
T2T Genomes Unveil Centromere Architecture and Adaptive Divergence in Large Yellow Croaker (Larimichthys crocea).
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- EasyCen: A Lightweight Framework for Centromere Localisation and Repeat-Organisation Profiling in Telomere-to-Telomere Genomes.Molecular ecology resources · 2026Article
- A highly contiguous chromosome-level genome assembly of the Chilean jack mackerel Trachurus murphyi.Scientific data · 2026Article
- A Loss-of-Function Mutation inAnimals : an open access journal from MDPI · 2026Article
- T2T Genomes Unveil Centromere Architecture and Adaptive Divergence in Large Yellow Croaker (Larimichthys crocea).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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10 authors.
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Abstract
The large yellow croaker (Larimichthys crocea) is a key aquaculture species, yet gaps in high-quality genomes hinder studies of centromeric and adaptive evolution. This study presents two telomere-to-telomere (T2T), gapless genomes from the Min-Yuedong (MYD) and Daiqu (DQ) populations, which diverged 4.18 million years ago. The centromeres are characterized by a 42 bp tandem repeat (Cen-42) and invasions by endogenous retrovirus 1 (ERV1) of long terminal repeat (LTR) elements. Both populations exhibit transcriptional activity in centromeric regions, but display significant divergence in gene number and composition, likely driven by rapid population expansion and selective pressure. In addition, 5S ribosomal RNA genes form ultra-large tandem repeat clusters in the short-arm regions of more than 10 chromosomes. The T2T genome assemblies resolve previously unassembled regions, identifying 533 and 351 new genes in T2T-MYD and T2T-DQ, respectively. Four population-specific structural variations, located in pla2g4a, eno2, ptprb, and itrp3 are identified. Comparative genomic analyses highlight distinct adaptive features between the two populations, including differences in metabolic efficiency, arachidonic acid metabolism, chemosensasory function, and circadian rhythm. Collectively, these findings deepen the understanding of L. crocea evolution and provide valuable genomic resources for its conservation and breeding.
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