ReviewCell communication and signaling : CCS2025
MreB: unraveling the molecular mechanisms of bacterial shape, division, and environmental adaptation.
Review in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Bacterial Sentience Is Determined by the Stochastic, Chaotic, and Deterministic Behavior of Cytoplasmic Particles.Current issues in molecular biology · 2026Review
- Synthesis of tunable copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate by engineeredSynthetic and systems biotechnology · 2026Article
- Multilevel Regulation of Peptidoglycan Dynamics in Bacteria: From Molecular Mechanisms to Applied Perspectives.Biomolecules · 2026Review
- Tetrahydrocarbazole as a Versatile Scaffold in Drug Discovery: A Cross-Target SAR Analysis and Design Paradigms.Molecules (Basel, Switzerland) · 2026Review
- From Host-Derived Pressures to the Environmental Anti-Antimicrobial Peptides Resistome: Mechanisms, Reservoirs and Implications for Therapeutic Peptide Design.Marine drugs · 2026Review
- Protein-Protein Interactions as Promising Molecular Targets for Novel Antimicrobials Aimed at Gram-Negative Bacteria.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
As a key bacterial actin-like protein, MreB plays crucial roles in maintaining cell shape, regulating peptidoglycan synthesis, and coordinating chromosome segregation, making it a promising target for novel antibiotics. This review comprehensively explores MreB’s molecular architecture, its assembly into antiparallel protofilaments, and its pivotal roles in bacterial cell morphology and division. We also delve into how MreB interacts with membrane-associated proteins such as RodZ and MreC/D to coordinate cell wall synthesis and respond to environmental signals like ion gradients and temperature changes. Furthermore, we highlight the cooperation and functional divergence between MreB and FtsZ, underscoring the evolutionary adaptability of bacterial cytoskeletal structures. The structural and functional parallels between MreB and eukaryotic cytoskeletal proteins are also examined, offering new insights into the evolution of cytoskeletal systems. By integrating insights from structural biology, synthetic biology, and microbial ecology, this review aims to provide a deeper understanding of MreB’s role in bacterial biology, its dynamic responses to environmental cues, and its implications for therapeutic innovation. This comprehensive analysis not only enhances our knowledge of bacterial self-organization mechanisms but also paves the way for the development of innovative antimicrobial strategies to address the growing challenge of antibiotic resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.