SynthesisBMC pediatrics2025
Interleukin-13 gene polymorphisms and asthma susceptibility in children: a meta-analysis.
Synthesis in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterleukin (IL)-13 is a central mediator of airway inflammation in asthma, and gene polymorphisms may play a role in asthma pathogensis. However, the relationship between IL-13 gene polymorphisms and asthma susceptibility remain unclear. Therefore, we conducted this meta-analysis to evaluate this relationship and better understand the risk of asthma in Chinese children. METHODS AND
resultsPubMed, cnki.net, China Wanfang, and Embase were searched to identify relevant case–control studies in Chinese children published until July 2021. In total, 217 Chinese and English articles were searched; 23 articles were included (19 Chinese and 4 English). Compared with genotype CC and allele C, genotypes TT, TC, and TT + TC at the rs1800925 (C-1112 T) loci and allele T, respectively, were not associated with the risk of bronchial asthma. At the rs1295686 (C + 1923 T) loci, compared with genotype CC, there were significant associations between genotypes TT, TC, and TT + TC and the risk of bronchial asthma. Compared with allele C, allele T increased the risk of bronchial asthma. At the rs20541 (G + 2044A) loci, compared with genotype GG, the genotypes AA and AA + GA were associated with the risk of bronchial asthma, but the genotype GA was not. Compared with allele G, allele A increased the risk of bronchial asthma.
conclusionsrs1295686 (C + 1923 T) and rs20541 (G + 2044A) gene polymorphisms are associated with asthma susceptibility, whereas rs1800925 (C-1112 T) gene polymorphisms are not.
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