Trial reportBMC oral health2025
Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06635369 (The Role of Taurine in Periodontitis and Aging), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Taurine in Periodontitis and Aging: a Preliminary Study
Who cites it
2 citing papers in PubMed.
- Association Between Salivary Sirtuin-1 Levels and Periodontitis.Journal of clinical medicine · 2026Article
- Impact of anti-TNF and anti-IL-12/IL-23 antibody therapy on periodontal inflammation and gingival crevicular fluid IL-6 in patients with inflammatory bowel diseases.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAging is a progressive decline in physiological & immunological functions, leading to an increased risk of chronic diseases. Taurine is a semi-essential amino acid, reduces inflammation by apoptosis, and oxidative stress by lowering inflammatory factors and decreases oxidative stress. The aim of this pilot study is to evaluate the saliva and serum levels of taurine and interrelated proteins in patients with periodontitis in different age groups. MATERIALS AND
methodsThe study included systemically healthy young (25–44 years old) and old (≥ 65 years old) periodontally healthy and stage III grade B periodontitis patients. Periodontal parameters and salivary flow rates were recorded. Serum and saliva samples were collected to measure the taurine, sirtuin 1(SIRT1), and TNF-α using ELISA kits.
resultsTaurine levels in saliva and serum were significantly elevated in the young periodontally healthy group compared to other groups (p < 0.05). SIRT1 levels in serum were also higher in the young healthy group (p < 0.05), while no significant difference was found in saliva. TNF-α positively correlates with the local inflammatory burden of periodontal disease (bleeding on probing and clinical attachment loss). TNF-α was found the most accurate biomarker (AUC = 0.711).
conclusionAccording to data of this pilot study, young individuals have higher levels of taurine compared to older individuals, and that this variation may be suggested as more strongly associated with age than with periodontal condition.
trial registrationNCT06635369 – 10/10/2024—Retrospectively registered.
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