Evidence map›Paper›PMID 40847250›Full record

ArticleNeuroscience bulletin2026

Hypothalamic Oxytocin Neuronal Activation Induces Bipolar-Like Mood Changes in Mice in a Sex- and Dosage-Dependent Manner.

Hong Tan, Shizhen Jin, Wenjin Lv, Lingyu Guo, Peiran Jiang, Yongjian Li, Mengjia Shi, Danting Wang, Yongcheng Wang, Aimin Bao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hong Tan *Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China.
Shizhen Jin *Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China.
Wenjin LvDepartment of Neurobiology and Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China.
Lingyu GuoDepartment of Neurobiology and Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China.
Peiran JiangNational Brain Bank for Health and Disease, Zhejiang University, Hangzhou, 310000, China.
Yongjian LiNHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Centre for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310000, China.
Mengjia ShiNHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Centre for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310000, China.
Danting WangNHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Centre for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310000, China.
Yongcheng WangNHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Centre for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, 310000, China.
Aimin BaoDepartment of Neurobiology and Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China. baoaimin@zju.edu.cn.ORCID http://orcid.org/0000-0002-8755-1950

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical studies have suggested that increased plasma oxytocin (OT) levels are a promising biomarker for bipolar disorder (BD), and our earlier post-mortem study found increased OT activity in the hypothalamic paraventricular nucleus (OT

Indexed as

Bipolar DisorderManiaNeuronsOxytocinParaventricular Hypothalamic NucleusSex CharacteristicsSupraoptic NucleusAnimalsBehavior, AnimalFemaleMaleMiceMice, Inbred C57BLMice, TransgenicPrefrontal CortexOxytocinBipolar disorderChemogeneticsHypothalamusMedial prefrontal cortexOxytocin

Identifiers

PMID40847250
PMCPMC13158320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.