Evidence map›Paper›PMID 40847243›Full record

ArticleNature immunology2025

SATB1 is a key regulator of quiescence in stem-like CD8

Siying Lin, Hongshen Niu, Yuqi Zhang, Kexin Gai, Ryan Brown, Ashley Brown, Jian Shen, Ziyang Xu, Ravi K Shah, Jessica L Schmeling and 6 more

Abstract read
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. SATB1 preserves CD4Life science alliance · 2026
    Article
  2. Exhausted CD8Nature immunology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Quiet custodians of CD8Nature immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Siying LinDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9993-7957
Hongshen NiuDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0009-0006-0657-6096
Yuqi ZhangDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Kexin GaiDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ryan BrownDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ashley BrownDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-1320-9327
Jian ShenDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8398-2318
Ziyang XuDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ravi K ShahDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0003-2802-1543
Jessica L SchmelingDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Marlenny Vargas-CortesDepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0009-0005-0834-4347
Anthony E ZamoraDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0001-5712-5339
Terumi Kohwi-ShigematsuDepartment of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA.
Jie FanDepartment of Medicine, Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Bin ZhangDepartment of Medicine, Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-6631-7647
Weiguo CuiDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. weiguo.cui@northwestern.edu.ORCID http://orcid.org/0000-0003-1562-9218

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Phenotypic, Functional and Transcriptional Heterogeneity in T Cell ExhaustionR01AI148403 · NIAID · VERSITI WISCONSIN, INC. · PI WEIGUO CUI · 2020 to 2026
$3.1M
Medical Scientist Training ProgramT32GM154638 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI Joseph T Barbieri, Nita H Salzman · 2025 to 2026
$1.8M
TCR signaling strength regulated T cell differentiation during chronic viral infectionR56AI176611 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CUI, WEIGUO · 2024 to 2024
$350k
Mechanisms by which PIM kinase modulates the effector function of autoreactive CD8 T cells in type 1 diabetesF30DK132807 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI Ashley K Brown · 2023 to 2026
$216k
NCI NIH HHS P30 CA060553NIAID NIH HHS R01 AI148403NIAID NIH HHS R56 AI176611NIDDK NIH HHS F30 DK132807NIGMS NIH HHS T32 GM080202NIGMS NIH HHS T32 GM154638U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI148403
6 · The paper itself

Abstract

Stem-like progenitor CD8

Indexed as

CD8-Positive T-LymphocytesLymphocytic ChoriomeningitisMatrix Attachment Region Binding ProteinsAnimalsImmunologic MemoryLymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, KnockoutMatrix Attachment Region Binding ProteinsSatb1 protein, mouse

Identifiers

PMID40847243
PMCPMC12492489

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.