Evidence map›Paper›PMID 40847236›Full record

ReviewCancer treatment and research2025

Pancreatic Cancer Immunotherapy: A Team-Based Approach.

Krushangi Patel, Percy Lee, Julius Weng, Laleh Melstrom, Mustafa Raoof, Aaron Lewis, Vincent Chung

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cancer treatment and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Krushangi PatelCity of Hope Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center Long Beach, Long Beach, CA, USA. KruPatel@coh.org.ORCID https://orcid.org/0009-0009-4431-5972
Percy LeeDepartment of Radiation Oncology, City of Hope Orange County Lennar Foundation Cancer Center, Irvine, CA, USA.
Julius WengDepartment of Radiation Oncology, City of Hope Orange County Lennar Foundation Cancer Center, Irvine, CA, USA.
Laleh MelstromDepartment of Surgical Oncology, City of Hope Comprehensive Cancer Center (COH), Duarte, CA, USA.
Mustafa RaoofDepartment of Surgical Oncology, City of Hope Comprehensive Cancer Center (COH), Duarte, CA, USA.
Aaron LewisDepartment of Surgical Oncology, City of Hope Comprehensive Cancer Center (COH), Duarte, CA, USA.
Vincent ChungDepartment of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapeutic approaches have created effective therapy with a manageable toxicity profile as a new treatment approach in a wide variety of cancers, often leading to longer responses and control of disease. In pancreatic cancer, responses to immunotherapy have been difficult to capture. Many obstacles have been identified in the limited efficacy of immunotherapy in pancreatic cancers. The hostile tumor microenvironment plays a large role in therapeutic development of immune-based therapies in pancreatic cancer. The approach to addressing many of these challenges will require a team-based approach to optimize both our understanding of the disease, its microenvironment, and how each component behaves in the development and growth of pancreatic cancer as well as the mechanisms used to best create therapies and combinations of treatment that will have long-standing efficacy for pancreatic cancer patients.

Indexed as

ImmunotherapyPancreatic NeoplasmsHumansTumor MicroenvironmentCytotoxic T-lymphocyte-associated protein 4 (CTLA-4)Immune checkpoint blockade (ICB)Overall response rate (ORR)Overall survival (OS)Pancreatic ductal adenocarcinoma (PDAC)Programmed cell death protein 1 (PD1)Progression-free survival (PFS)Tumor-infiltrating lymphocyte therapy (TILs)Tumor microenvironment (TME)

Identifiers

PMID40847236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.