Evidence map›Paper›PMID 40847232›Full record

ReviewCancer treatment and research2025

Immunotherapy in Head and Neck Cancer.

Bridget E Crossman, Regan L Harmon, Mari Iida, Candie Y Lin, Jennifer Yoon, Evan P Pisick, Ravi Salgia, Tiffany Glazer, Randall Kimple, Justine Yang Bruce and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cancer treatment and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bridget E CrossmanDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.
Regan L HarmonDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.
Mari IidaDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.
Candie Y LinDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.
Jennifer YoonDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.
Evan P PisickCity of Hope Chicago, Zion, IL, USA.
Ravi SalgiaDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA.
Tiffany GlazerDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Randall KimpleDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.
Justine Yang BruceCarbone Cancer Center, University of Wisconsin, Madison, WI, USA.
Deric WheelerDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA. dlwheeler@wisc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck cancer (HNC) is the seventh most common cancer worldwide, with incidence growing every year. While the standard regimen of surgery, chemotherapy, radiotherapy, targeted anti-EGFR therapy, and immune checkpoint inhibition are effective in a subset of patients, therapeutic resistance is a persistent challenge for managing this disease. The use of immunotherapeutic agents to treat HNC has risen over recent years, with advances in immune checkpoint inhibition, targeted therapy with bispecific antibodies, modified cytokine delivery, adoptive cell therapy, and virus-based therapeutics making their way into clinical trials for HNC. This chapter also discusses ongoing investigations into combinatorial strategies and biomarkers aimed at improving outcomes for patients with HNC.

Indexed as

Head and Neck NeoplasmsImmunotherapyHumansImmune Checkpoint InhibitorsImmune Checkpoint InhibitorsHead and neck cancerHead and neck squamous cell carcinomaHNCHNSCCImmunotherapy

Identifiers

PMID40847232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.