Evidence map›Paper›PMID 40847222›Full record

ArticleCardiovascular and interventional radiology2025

One- and Two-Year Outcomes of Genicular Artery Embolization for Symptomatic Knee Osteoarthritis: A Single-Center, Retrospective Study Using 200-µm Polyethylene Glycol Microspheres.

Wali Badar, Faisal Al-Qawasmi, Layth Alkhani, Ajay Varadhan, Abin Sajan, Qian Yu, Magdalena Anitescu, Brendon Ross, Sara Wallace, Mikin Patel and 1 more

Abstract read
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In one paragraph

Article in Cardiovascular and interventional radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. We Saved the Best for Last….Cardiovascular and interventional radiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wali BadarDepartment of Radiology, University of Illinois at Chicago, 1740 West Taylor Avenue, Chicago, IL, USA. wbadar2@uic.edu.
Faisal Al-QawasmiCollege of Medicine, University of Illinois at Peoria, Peoria, IL, USA.
Layth AlkhaniSchool of Engineering, Stanford University, Palo Alto, CA, USA.
Ajay VaradhanCollege of Medicine, University of South Florida, Tampa Bay, FL, USA.
Abin SajanDepartment of Radiology, Columbia University, New York, NY, USA.
Qian YuDepartment of Radiology, University of Chicago, Chicago, IL, USA.
Magdalena AnitescuDepartment of Anesthesia, University of Chicago, Chicago, IL, USA.
Brendon RossDepartment of Orthopedic Surgery and Rehabilitation Medicine, University of Chicago, Chicago, IL, USA.
Sara WallaceDepartment of Orthopedic Surgery and Rehabilitation Medicine, University of Chicago, Chicago, IL, USA.
Mikin PatelDepartment of Radiology, University of Chicago, Chicago, IL, USA.
Osman AhmedDepartment of Radiology, University of Chicago, Chicago, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate one- and two-year outcomes of genicular artery embolization (GAE) using 200-µm permanent microspheres in patients with symptomatic knee osteoarthritis (KOA) and identify predictors of clinical response. Long-term GAE outcome data are sparse but necessary to understand durability of the intervention. MATERIAL AND

methodsA single-center, IRB-approved retrospective study including 34 consecutive patients received GAE for symptomatic KOA from September 2021 to January 2024. GAE was performed using 200-µm polyethylene glycol microspheres. Clinical outcomes were assessed with the Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scoring system at pre-GAE visit and up to 2 years post-GAE. A 20% reduction in the WOMAC pain score at 1 and 2 years was considered clinically significant as well as by the OARSI-Osteoarthritis Research Society International Standing Committee for Clinical Trials Response Criteria Initiative and the Outcome Measures in Rheumatology criteria (OMERACT). Kaplan-Meier analysis was performed to investigate clinical response over time. Univariate and multivariate analysis was performed for gender, race, age, BMI, vessels treated, embolic volume, Kellgren-Lawrence (KL) grading using Fisher and t-tests.

resultsThirty-four patients and 42 knees were treated with KOA severity: KL3 ≥ 90%. One-year proportion of clinical response by MCID: 23.8% (95% CI 13.9-40.9) and by OMERACT: 21.4% (95% CI 12.0-38.2). Two-year proportion of clinical response by MCID: 19.8% (95% CI 10.4-38.0) and by OMERACT: 16.1% (95% CI 7.2-36.1). Adverse event rate was 30.1%. BMI was predictive of categorical response (univariate: P = 0.012 and multivariate: P = 0.033).

conclusionGAE using 200-µm PEG microspheres shows modest long-term outcomes for KOA with acceptable safety profile.

Indexed as

Embolization, TherapeuticOsteoarthritis, KneePolyethylene GlycolsAgedFemaleHumansMaleMicrospheresMiddle AgedRetrospective StudiesTreatment OutcomePolyethylene GlycolsGAEGenicular artery embolizationKnee osteoarthrititsLong-term outcomesMicrospheresPolyethylene glycol

Identifiers

PMID40847222

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.