Evidence map›Paper›PMID 40847198›Full record

ArticleLeukemia2025

Predicting antigen-specific T-cell immunity against Wilms tumor 1 in hematologic cancer.

Brittany L Ford, Emmi Jokinen, Jani Huuhtanen, Sofia Forstén, Jay Klievink, Gabriella Antignani, Oscar Brück, Vincenzo Cerullo, iCAN, Karita Peltonen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brittany L Ford *Translational Immunology Research Program (TRIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0003-2301-7799
Emmi Jokinen *Translational Immunology Research Program (TRIMM), University of Helsinki, Helsinki, Finland.
Jani HuuhtanenTranslational Immunology Research Program (TRIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0003-2750-4033
Sofia ForsténTranslational Immunology Research Program (TRIMM), University of Helsinki, Helsinki, Finland.ORCID 0009-0002-4835-3334
Jay KlievinkTranslational Immunology Research Program (TRIMM), University of Helsinki, Helsinki, Finland.
Gabriella AntignaniTranslational Immunology Research Program (TRIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0001-9388-8632
Oscar BrückHematoscope Lab, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-7842-9419
Vincenzo CerulloTranslational Immunology Research Program (TRIMM), University of Helsinki, Helsinki, Finland.
iCAN
Karita PeltonenTranslational Immunology Research Program (TRIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3063-451X
Satu MustjokiTranslational Immunology Research Program (TRIMM), University of Helsinki, Helsinki, Finland. satu.mustjoki@helsinki.fi.ORCID 0000-0002-0816-8241

Funding

Suomen Kulttuurirahasto (Finnish Cultural Foundation) 00220227, 00240108
6 · The paper itself

Abstract

Wilms tumor 1 (WT1) is a tumor-associated antigen expressed in solid tumors and hematological malignancies. T-cell immunotherapies targeting WT1 are currently under development. To analyze endogenous T-cell responses against WT1, we trained computational models capable of detecting WT1-specific T-cell responses from T-cell receptor (TCR) sequencing data. We peptide-pulsed healthy donor and acute myeloid leukemia (AML) patient samples with VLDFAPPGA (VLD, WT1

Indexed as

Antigens, NeoplasmCD8-Positive T-LymphocytesHematologic NeoplasmsT-LymphocytesWT1 ProteinsEpitopes, T-LymphocyteHumansMachine LearningReceptors, Antigen, T-Cell, alpha-betaAntigens, NeoplasmEpitopes, T-LymphocyteReceptors, Antigen, T-Cell, alpha-betaWT1 protein, humanWT1 Proteins

Identifiers

PMID40847198
PMCPMC12589112

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.