SynthesisScientific reports2025
Psychological intervention in patients with central sensitization syndromes and comorbid psychosocial trauma: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Distinct pain profiles across irritable bowel syndrome subtypes: results from the Rome Foundation Global Epidemiology Study.Internal and emergency medicine · 2026Article
- Central Sensitization as a Marker of Cognitive and Emotional Vulnerability in Chronic Low Back Pain.Brain sciences · 2026Article
- Association Between Fibromyalgia and Lower Urinary Tract Pain and Storage Symptoms in Women: A Systematic Review and Meta‑analysis.Journal of pain research · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The co-occurrence of central sensitization syndromes (CSS) and post-traumatic symptoms (PTSS) or post-traumatic stress disorder (PTSD) exacerbates impairment, and treatment is unsatisfactory in many cases. This systematic review and meta-analysis examined the effectiveness of psychological therapy in individuals with CSS and comorbid PTSS/PTSD. A search of Medline, PsycInfo, Web of Science, Pubmed, and Scopus databases (2000 to 2023) was conducted following PRISMA guidelines. Nineteen articles were selected, including nine for meta-analysis. The main psychological therapies were pain-focused cognitive-behavioral therapy (P-CBT), and trauma-focused interventions, mainly written emotional disclosure (WED) and emotional awareness and expression therapy (EAET). Both EAET and P-CBT showed potential benefits in improving pain severity (specially EAET), PTSS/PTSD, emotional distress, fatigue, sleep disturbances, CSS-related symptoms, and quality of life. Overall, no significant differences were found between the two interventions. The meta-analysis revealed a large effect size for EAET in reducing pain and emotional distress; however, most comparison were against inactive controls, so results should be interpreted cautiously. These findings underscore the importance of distinguishing CSS patients with PTSS/PTSD. Tailored treatments such as EAET can address the additive impact of these conditions and contribute to improving patients' quality of life.
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