ArticleBreast cancer (Tokyo, Japan)2025
Impact of radiation therapy on breast satisfaction and health-related quality of life after breast reconstruction: a multicenter cross-sectional controlled study (Reborn study-02).
Article in Breast cancer (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Breast reconstruction-related complications from postmastectomy radiation therapy in stage II-III breast cancer: sub-analysis of a multi-institutional observational study (Reborn-03).Breast cancer (Tokyo, Japan) · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-mastectomy radiation therapy (PMRT) is essential for reducing recurrence in patients with high-risk breast cancer but may negatively impact breast reconstruction outcomes. The impacts of PMRT on breast satisfaction and health-related quality of life (HR-QOL) remain unclear, particularly in Japanese patients. We evaluated the impact of PMRT on breast satisfaction and HR-QOL using BREAST-Q.
methodsA multicenter, cross-sectional study was conducted at 10 institutions in Japan. Patients who underwent breast reconstruction with or without PMRT were surveyed using the Japanese version of the BREAST-Q. Endpoints included breast satisfaction and HR-QOL domains (physical, psychosocial, and sexual well-being). Multivariate analysis was performed to identify factors influencing these outcomes.
resultsOverall, 1078 patients with primary breast cancer who underwent breast reconstruction were included in this study, with a questionnaire response rate of 77.0% (830/1,078). Data from 830 patients were analyzed (PMRT group: 214, non-PMRT group: 616). The PMRT group had significantly lower breast satisfaction (50.7 vs. 57.5, P < 0.001), physical well-being (70.2 vs. 82.4, P < 0.001), and psychosocial well-being (51.2 vs. 56.4, P < 0.001). There was no significant difference in sexual well-being. PMRT was a predictor of reduced breast satisfaction, physical well-being, and psychosocial well-being.
conclusionsPMRT was associated with decreased breast satisfaction and HR-QOL in patients with reconstructed breasts. Patients should be given comprehensive information regarding the potential impacts of PMRT on breast satisfaction and HR-QOL. Shared decision-making based on realistic preoperative expectations is critical for optimal patient outcomes and satisfaction with treatment modalities.
Indexed as
Identifiers
40847020What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.