ArticleEuropean journal of medical research2025
Clinical significance of androgen receptor in unilateral invasive breast cancer in women.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo assess the prognostic relevance of androgen receptor (AR) expression in patients following modified radical surgery for invasive breast cancer.
methodsA cohort of 515 patients who underwent modified radical mastectomy for breast cancer from July 2016 to November 2017 was analyzed. Immunohistochemistry was employed to determine the expression levels of AR, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), cell proliferation nuclear antigen (Ki-67), oncogene (P-53), cytokeratin 5/6 (CK5/6), topoisomerase-2 (TOPO-2), and epidermal growth factor receptor (EGFR). The correlation between AR expression and clinicopathological features as well as prognosis was examined. Multifactorial analysis using Cox proportional risk regression identified independent prognostic factors for disease-free survival (DFS), and a nomogram model was developed based on these factors.
resultsPatients in the AR-positive group demonstrated a significantly higher frequency of low histologic grade (grade 1-2), ER positive, PR positive, TOPO-2-negative, CK5/6-negative, and EGFR-negative as compared to the AR-negative group (P < 0.05). Among ER( +)/HER-2(-) and ER( +)/HER-2( +) patients with breast cancer, AR-positive individuals exhibited prolonged DFS (P < 0.05). Conversely, in ER(-)/HER-2( +) and ER(-)/HER-2(-) patients with breast cancer, AR expression did not significantly influence disease-free survival (P > 0.05). Multifactorial regression analysis identified AR/ER ratio, histological classification, and lymph node metastasis as independent prognostic factors for DFS (all P < 0.05). The developed nomogram model underscored the significance of histological classification as the primary predictive factor for patient outcomes, followed by AR/ER ratio and lymph node metastasis
conclusionAR expression holds varying prognostic implications across different breast cancer subtypes, with AR positivity indicating a favorable prognosis, particularly in ER-positive tumors.
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