Evidence map›Paper›PMID 40846985›Full record

ArticleBMC research notes2025

Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry.

Eirini Chatzopoulou, Galinos Fanourakis, Nikolaos Papanikolaou, Ioulia Chatzistamou, Xanthippi Dereka, Heleni Vastardis

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In one paragraph

Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eirini Chatzopoulou *U.F.R. d'Odontologie, Université Paris Cité, 1 Rue Maurice Arnoux, Montrouge, Paris, 92120, France.
Galinos Fanourakis *Department of Oral Biology, School of Dentistry, National and Kapodistrian University of Athens, 2 Thivon Str, Goudi, Athens, 11527, Greece. gfanourak@med.uoa.gr.
Nikolaos PapanikolaouEnzyQuest PC, Science and Technology Park of Crete, 100 Nikolaou Plastira Str., Vassilika Vouton, Heraklion, 70013, Greece.
Ioulia ChatzistamouDepartment of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, 6439 Garners Ferry Road Columbia, Columbia, SC, 29209, USA.
Xanthippi DerekaDepartment of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, 2 Thivon Str, Goudi, Athens, 11527, Greece.
Heleni VastardisDepartment of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 2 Thivon Str, Goudi, Athens, 11527, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveG protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study.

resultsNo variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.

Indexed as

Genetic Predisposition to DiseasePeriodontitisPolymorphism, Single NucleotideReceptors, G-Protein-CoupledWhite PeopleAdultAllelesCase-Control StudiesFemaleGenotypeGreeceHumansMaleMiddle AgedADGRG6 protein, humanReceptors, G-Protein-CoupledGPR126 genePeriodontitisPolymorphism

Identifiers

PMID40846985
PMCPMC12374417

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.