Evidence map›Paper›PMID 40846868›Full record

ArticleNPJ science of food2025

Portable and affordable device for on-site quantitative detection of somatic cells in milk.

Yathirajarao Tammineni, Pankaj Kumar, Shashidhar Reddy, Muskan, Komal Birader, Kapil Kumar, Anitha Arumugam, Sujit Saha, Nilesh Nayee, Pankaj Suman

Abstract read
In one paragraph

Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yathirajarao TammineniNational Institute of Animal Biotechnology, Hyderabad, India.
Pankaj KumarNational Institute of Animal Biotechnology, Hyderabad, India.
Shashidhar ReddyNational Institute of Animal Biotechnology, Hyderabad, India.
MuskanNational Institute of Animal Biotechnology, Hyderabad, India.
Komal BiraderNational Institute of Animal Biotechnology, Hyderabad, India.
Kapil KumarNational Institute of Animal Biotechnology, Hyderabad, India.
Anitha ArumugamNational Institute of Animal Biotechnology, Hyderabad, India.
Sujit SahaNational Dairy Development Board, Anand, India.
Nilesh NayeeNational Dairy Development Board, Anand, India.
Pankaj SumanNational Institute of Animal Biotechnology, Hyderabad, India. pankajsuman@niab.org.in.

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/PR41122/ATGC/127/48/2020
6 · The paper itself

Abstract

Antimicrobial resistance in mastitis-associated pathogens has heightened concerns over the safety of raw milk, which transmits pathogens from animals to humans. Elevated somatic cell count (SCC) is widely recognized as a key indicator of microbial quality in milk, often linked to mastitis infections. High SCC alters milk composition, compromises milk quality, and reduces shelf life, rendering it unsuitable for consumption. Current methods for quantitative SSC, such as flow cytometry and microscopy, are effective but impractical for on-site applications. To bridge this gap, we developed QuantM, a portable and affordable device that employs amine-functionalized iron oxide nanoparticles to isolate somatic cells from milk via surfactant-induced aggregation. It quantifies SCC in field conditions within 10 minutes, achieving 94.74% sensitivity, 90.0% specificity, and 94.74% accuracy, with a detection limit of 0.017 million cells/mL compared to flow cytometry. This low-cost solution (<$0.10 per test) promises to enhance milk quality and safeguard public health.

Identifiers

PMID40846868
PMCPMC12373863

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.