Evidence map›Paper›PMID 40846856›Full record

ArticleNature communications2025

Biomimetic magnetobacterial microrobots for active pneumonia therapy.

Lishan Zhang, Ze Chen, Hui Ran, Mirai Azechi, Xue Yang, Weichang Huang, Hao Tian, Lihan Shen, Fei Peng, Yingfeng Tu

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lishan Zhang *NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Ze Chen *Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen, China.
Hui Ran *NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Mirai AzechiNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Xue YangNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Weichang HuangNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Hao TianNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Lihan ShenDepartment of Critical Care Medicine, Dongguan Institute of Respiratory and Critical Care Medicine, Affiliated Dongguan Hospital, Southern Medical University, Dongguan, China. shenlihan@hotmail.com.
Fei PengSchool of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou, China. pengf26@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0001-8817-3472
Yingfeng TuNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China. tuyingfeng1@smu.edu.cn.ORCID http://orcid.org/0000-0003-2605-0172

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22175083
6 · The paper itself

Abstract

Immense progress in synthetic micro-/nanorobots with diverse functionalities has been made for biomedical applications during the last decade. However, there is still a huge gap for miniature robots to realize efficient therapy from in vitro to in vivo level. Here click chemistry is used to introduce curcumin-loaded hybrid cell membrane nanoparticles to magnetotactic bacteria AMB-1 with magnetic actuation, thus creating biohybrid microrobots CurNPs@2TM-AMB-1 for active and efficient pneumonia therapy in vivo. In the presence of an external rotating magnetic field, the developed AR are capable of moving controllably and wirelessly, and efficiently scavenging inflammatory factors and SARS-CoV-2 pseudovirus due to the existing receptors from the cell membrane cloaking strategy, thereby inhibiting the virus invasion and reducing the damage of inflammation to the lungs. Due to the active movement, AR significantly increase and prolong the accumulation of Cur in the lungs in vivo, thus alleviating the pneumonia and regulating pneumonia microenvironment. The designed hybrid microrobot system, with magnetic actuation and active neutralization of inflammatory factors and virus, shows great promise as a potential platform for pneumonia therapy.

Indexed as

BiomimeticsCOVID-19 Drug TreatmentPneumoniaRoboticsAnimalsBiomimetic MaterialsClick ChemistryCOVID-19CurcuminHumansLungMiceNanoparticlesSARS-CoV-2Curcumin

Identifiers

PMID40846856
PMCPMC12373794

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.