ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
MicroRNA-126 as an endogenous molecule for hypoxic/ischemic tolerance in neuroprotection.
Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mechanical pressure on endothelial cells mediates remote ischaemic preconditioning-induced neuroprotection via miR-126.Experimental physiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Hypoxic and ischaemic brain injuries are notable contributors to neurological disability and mortality, posing major global public health challenges. Notably, microRNA-126 (miR-126) has emerged as a key regulator in the complex pathophysiology of stroke. Hypoxic/ischaemic (HI) preconditioning upregulates miR-126, offering protection against HI brain injury. This article reviews the advances in understanding the molecular regulation of miR-126, focusing on epigenetic modifications, transcription factors, and hypoxia. miR-126 is crucial for modulating inflammation, promoting angiogenesis and neurogenesis, and supporting post-stroke recovery. Additionally, we highlight the therapeutic potential of exosomal miR-126 in treating HI brain injury.
Indexed as
Identifiers
40846814What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.