Evidence map›Paper›PMID 40846813›Full record

ArticleTheoretical medicine and bioethics2025

Is pharmacogenetics being racialized? An investigation into the reinscription of racial beliefs in modern biomedicine.

Lena Steimle, Christina Schües

Abstract read
In one paragraph

Article in Theoretical medicine and bioethics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lena SteimleFaculty of Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Christina SchüesInstitute for the History of Medicine and Science Studies, University of Lübeck, Königstraße 42, 23552, Lübeck, Germany. c.schuees@uni-luebeck.de.ORCID 0000-0002-8533-2527

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Racial classifications have a complex and troubled past in the social and scientific history of humankind. They are the result of racism and have been used to devalue and degrade non-White people. Although the concept of race has acquired a social component and the genetic similarity of people based on race has been proven, the category is increasingly used in pharmacogenetic studies to create biased study populations under the guise of personalized medicine. The heart failure drug BiDil, which was only approved for Black people in 2005, gained particular notoriety. Its race-specific approval reignited the debate about the assumption that there are genetic differences between people of different races and led to a further biopolitical instrumentalization of the term 'race'. Despite the expiry of the race-specific patent, race-specific labeling continues to take place in research. In this paper, these racializations of pharmacogenetics are examined, explaining how they arise and how they are kept alive. Finally, this paper argues for better moderation of race in pharmacogenetic studies.

Indexed as

PharmacogeneticsPrecision MedicineRacial GroupsRacismDrug CombinationsHeart FailureHumansHydralazineIsosorbide DinitrateDrug CombinationsHydralazineIsosorbide Dinitrateisosorbide-hydralazine combinationGenetic diversityPharmacogeneticsRacializationRacism

Identifiers

PMID40846813
PMCPMC12432089

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.