ReviewNature structural & molecular biology2025
Mechanisms and genomic implications of break-induced replication.
Review in Nature structural & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Kinetic Control of Condensate Function: How the Formation Dynamics of APBs Influence ALT Cancer Telomere Length Heterogeneity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Determinants of dicentric chromosome breakage inbioRxiv : the preprint server for biology · 2026Article
- Distinct repair outcomes from single and convergent replication fork collapse.Nature structural & molecular biology · 2026Article
- PHF20 stabilizes the GAS7-F-actin axis to drive DNA damage repair and chemoresistance in cutaneous squamous cell carcinoma.Cell death & disease · 2026Article
- Dissecting the role of PCNA and Pif1 in replication of individual DNA molecules by DNA polymerase δ.bioRxiv : the preprint server for biology · 2026Article
- Highly mutagenic copying of telomeric circles promotes ALT establishment.Nature communications · 2026Article
- Closing 2025, and a look ahead.Nature structural & molecular biology · 2025Article
- Learning about break-induced replication from bacteriophages.Nature reviews. Molecular cell biology · 2025Article
- Distinct roles of RECQL5 in RAD51-mediated fork reversal and transcription elongation.Nucleic acids research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
DNA double-strand breaks (DSBs) are a severe threat to genome stability, as DSB-repair mechanisms with low fidelity contribute to loss of genome integrity. Break-induced replication (BIR) is a crucial DSB-repair pathway when classical homologous recombination mechanisms fail. BIR is often triggered by stalled or collapsed replication forks, following extensive end resection that generates a single-stranded DNA substrate, which can engage either canonical homology-driven BIR, or microhomology-mediated BIR (mmBIR), which requires shorter sequence homologies than does canonical BIR. BIR is a double-edged sword: it is necessary for DSB repair, but is also culpable for introducing mutations and structural variations that are linked to cancer and genetic disorders. In this Review, we discuss BIR regulation in mammalian cells, and the role of BIR in telomere maintenance and in human disease, as well as in genome engineering. We highlight emerging findings in these areas and advances in technologies that have enabled their discovery and reshape our understanding of this enigmatic repair mechanism.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.