ArticleNature communications2025
A spatial single-cell atlas of the claustro-insular region uncovers key regulators of neuronal identity and excitability.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Spatiotemporal development of sparse excitatory neuronal types within the deep mouse cortex.iScience · 2026Article
- The claustrum encodes and scales appetitive feeding.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Pyramidal cell types and circuit organization of the mouse insular cortex reveal functional specializations.Nature neuroscience · 2026Article
- New functional insights from the monkey claustrum.National science review · 2026Review
- Article
- Article
- Cell-type-specific sustained value representations in the claustrum.bioRxiv : the preprint server for biology · 2026Article
- Bidirectional interaction between protocadherin 8 and the transcription factor Dbx1 regulates cerebral cortex development.Development (Cambridge, England) · 2026Article
- Cooperation of transposable elements to endow global networks of initiators of hybrid assembly pathways of endogenous multiprotein complexes.Frontiers in cellular and infection microbiology · 2026Article
- Direct interoceptive input to the insular cortex shapes learned feeding behavior.bioRxiv : the preprint server for biology · 2025Article
- Pain in the claustrum.Neurobiology of pain (Cambridge, Mass.)Review
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The claustro-insular region is an evolutionarily conserved and extensively interconnected brain area, critical for functions such as attention, cognitive flexibility, interoception, and affective processing. Despite its importance, its cellular composition and organization remain poorly characterized, hindering a comprehensive understanding of the mechanisms underlying its diverse functions. By combining single-cell RNA sequencing and spatial transcriptomics, we create a high-resolution atlas of this region in mice, uncovering distinct neuronal subtypes and unexpected complexity. Leveraging this atlas, we investigate the role of NR4A2, a neuropsychiatric risk factor expressed in several claustro-insular neuronal subtypes. In an Nr4a2 haploinsufficiency model, we find that only claustrum neurons exhibited shifts in molecular identity. This identity shift, which involves the activation of a transcription factor cascade, is associated with alterations in neuronal firing activity. Our findings provide new insights into the cellular architecture of the claustro-insular region and highlights Nr4a2 as a key regulator of its component's identities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.