Evidence map›Paper›PMID 40846796›Full record

Trial reportClinical oral investigations2025

Bleaching with biocatalysts and violet LED: a randomized clinical trial using a hybrid design with parallel-group and split-mouth approaches : Violet LED and biocatalysts in in-office whitening: a split-mouth trial.

Lara Maria Bueno Esteves, Carlos Alberto de Souza Costa, Luciano Tavares Angelo Cintra, Karen Milaré Seicento Aidar, Cristina de Mattos Pimenta Vidal, Alice de Oliveira Santos, André Luiz Fraga Briso

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lara Maria Bueno EstevesDepartment of Restorative Dentistry, Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, SP, Brazil.
Carlos Alberto de Souza CostaDepartment of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Araraquara, SP, Brazil.
Luciano Tavares Angelo CintraDepartment of Restorative Dentistry, Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, SP, Brazil.
Karen Milaré Seicento AidarDepartment of Restorative Dentistry, Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, SP, Brazil.
Cristina de Mattos Pimenta VidalDepartment of Operative Dentistry, College of Dentistry, The University of Iowa, Iowa City, IA, USA.
Alice de Oliveira SantosDepartment of Restorative Dentistry, Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, SP, Brazil.
André Luiz Fraga BrisoDepartment of Restorative Dentistry, Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, SP, Brazil. andre.briso@unesp.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 156744/2021-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 303500/2019-0Institutional Internationalization Program - CAPES/PRINT 88887.802663/2023-00São Paulo Research Foundation 2022/04364-6
6 · The paper itself

Abstract

objectiveTo compare conventional 35% hydrogen peroxide whitening for 45 min with test therapies lasting 15 min using a polymeric scaffold, peroxidase, and violet LED. MATERIALS AND

methodsSixty patients were randomized into three groups (n = 20): TC45 (35% HP for 45'), T15 (35% HP for 15'), and TT (polycaprolactone scaffold + 35% HP with peroxidase for 15'). One hemiarch was irradiated with violet LED (L) (8 cycles of 1 min, with 30-second intervals). ΔE

resultsThe TT group showed ΔE

conclusionTherapies using scaffold and peroxidase, with or without LED, were effective, safe, and less sensitive, representing promising alternatives to conventional whitening, even with a two-third reduction in application time. CLINICAL RELEVANCE: Whitening therapies using polymeric scaffold and peroxidase, with or without violet LED, are effective, safe, and cause less sensitivity, representing promising alternatives to conventional whitening.

Indexed as

Hydrogen PeroxidePeroxidaseTooth BleachingTooth Bleaching AgentsAdultBiocatalysisFemaleHumansMaleMiddle AgedPolyestersTreatment OutcomeHydrogen PeroxidePeroxidasepolycaprolactonePolyestersTooth Bleaching AgentsColor changeHorseradish peroxidaseTooth sensitivityTooth whiteningViolet led

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.