Evidence map›Paper›PMID 40846748›Full record

ArticleScientific reports2025

Impaired nutrient absorption, reduced bone mass and alterations in the gut microbiome contribute to postnatal growth retardation in a mouse model of MWS.

Yangyang Ge, Lingya Liu, Lihua Wu, Xiaofan Liu, Yingao Hao, Shixu Wang, Yi Xiong, Zi Yang, Zhen Zhang, Qi Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yangyang GeDepartment of Medical Genetics, Capital Institute of Pediatrics, Beijing, 100020, China.
Lingya LiuDepartment of Medical Genetics, Capital Institute of Pediatrics, Beijing, 100020, China.
Lihua WuDepartment of Medical Genetics, Capital Institute of Pediatrics, Beijing, 100020, China.
Xiaofan LiuInstitute of Food and Nutrition Development, Ministry of Agriculture and Rural Affairs of the Reople's Republic of China, Beijing, 100081, China.
Yingao HaoInstitute of Food and Nutrition Development, Ministry of Agriculture and Rural Affairs of the Reople's Republic of China, Beijing, 100081, China.
Shixu WangInstitute of Food and Nutrition Development, Ministry of Agriculture and Rural Affairs of the Reople's Republic of China, Beijing, 100081, China.
Yi XiongDepartment of General Surgery, Capital Center for Children's Health, Capital Medical University, Beijing, 100020, China.
Zi YangDepartment of Medical Genetics, Capital Institute of Pediatrics, Beijing, 100020, China.
Zhen ZhangDepartment of General Surgery, Capital Center for Children's Health, Capital Medical University, Beijing, 100020, China.
Qi LiDepartment of General Surgery, Capital Center for Children's Health, Capital Medical University, Beijing, 100020, China.
Bo LiDepartment of Translational Medicine, Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Jianxin WuBeijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. jianxinwu_2000@163.com.
Guangxu RenInstitute of Food and Nutrition Development, Ministry of Agriculture and Rural Affairs of the Reople's Republic of China, Beijing, 100081, China. renguangxu@caas.cn.
Qian JiangDepartment of Medical Genetics, Capital Institute of Pediatrics, Beijing, 100020, China. jiangqian@pumc.edu.cn.

Funding

Beijing Finance Bureau CIP2024-0040Beijing Municipal Administration of Hospitals Incubating Program PX2020054Beijing Municipal Administration of Hospitals Incubating Program PX2022054National Natural Science Foundation of China 82370522, 82070532National Natural Science Foundation of China 82400215Research Foundation of Capital Institute of Pediatrics CXYJ-2021-05Research Foundation of Capital Institute of Pediatrics JCYJ-2023-04Research Unit of Minimally Invasive Pediatric Surgery on Diagnosis and Treatment, Chinese Academy of Medical Sciences 2021RU015
6 · The paper itself

Abstract

Mowat‒Wilson syndrome (MWS), a rare genetic disorder caused by heterozygous loss-of-function mutations in ZEB2, is characterised by significant growth retardation with unclear mechanisms. In this study, we developed a Zeb2 haploinsufficient (Zeb2

Indexed as

Gastrointestinal MicrobiomeGrowth DisordersHirschsprung DiseaseIntestinal AbsorptionNutrientsAnimalsBone and BonesBone DensityDisease Models, AnimalDysbiosisHaploinsufficiencyMaleMiceZinc Finger E-box Binding Homeobox 2NutrientsZEB2 protein, mouseZinc Finger E-box Binding Homeobox 2Bone massMicrobiotaNutrient absorptionSmall intestineZeb2

Identifiers

PMID40846748
PMCPMC12373963

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.