Evidence map›Paper›PMID 40846642›Full record

ArticleGenes & development2025

A kinetic ruler controls mRNA poly(A) tail length.

Emilie Gabs, Emil Aalto-Setälä, Aada Välisaari, Anssi M Malinen, Torben Heick Jensen, Stephen H McLaughlin, Lori A Passmore, Matti Turtola

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Analysis ofMicroorganisms · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emilie GabsDepartment of Life Technologies, University of Turku, Turku 20520, Finland.
Emil Aalto-SetäläDepartment of Life Technologies, University of Turku, Turku 20520, Finland.ORCID 0000-0002-8161-1107
Aada VälisaariDepartment of Life Technologies, University of Turku, Turku 20520, Finland.
Anssi M MalinenDepartment of Life Technologies, University of Turku, Turku 20520, Finland.ORCID 0000-0003-2987-2649
Torben Heick JensenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus 8000, Denmark.ORCID 0000-0001-5127-1239
Stephen H McLaughlinLaboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0001-9135-6253
Lori A PassmoreLaboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0003-1815-3710
Matti TurtolaDepartment of Life Technologies, University of Turku, Turku 20520, Finland; matti.turtola@utu.fi.ORCID 0000-0003-1694-1027

Funding

Wellcome Trust
6 · The paper itself

Abstract

Poly(A) tails of newly synthesized mRNAs have uniform lengths, arising through cooperation between the cleavage and polyadenylation complex (CPAC) and poly(A) binding proteins (PABPs). In the budding yeast

Indexed as

Poly ARNA-Binding ProteinsRNA, MessengerSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsKineticsNucleocytoplasmic Transport ProteinsPoly(A)-Binding ProteinsPolyadenylationProtein BindingProtein MultimerizationNAB2 protein, S cerevisiaeNucleocytoplasmic Transport ProteinsPoly APoly(A)-Binding ProteinsRNA-Binding ProteinsRNA, MessengerSaccharomyces cerevisiae ProteinsCCCH zinc finger proteincleavage and polyadenylation complex (CPAC)kinetic rulermRNA polyadenylationNab2poly(A) binding protein (PABP)poly(A) tailRNA-binding proteinZC3H14

Identifiers

PMID40846642
PMCPMC12581835

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.