ArticleLife science alliance2025
Protein arginine methyltransferase 5 sustains Tip60-EP400 complex via SRSF1 in Merkel cell carcinoma.
Joseph L Sevigny, Evelyn V Proctor, Heather Adams, Erin R MacDonald, W Kelley Thomas, Jingwei Cheng
Abstract read
In one paragraphArticle in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Joseph L SevignyDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Evelyn V ProctorDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.ORCID 0000-0001-7968-4828 Heather AdamsDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Erin R MacDonaldDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
W Kelley ThomasDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA.
Jingwei ChengDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, USA jingwei.cheng@gmail.com.ORCID 0000-0003-3832-0897 Funding
Ultrastructural analysis of axonal Kv2-mediated endoplasmic reticulum/plasma membrane (ER/PM) junctionsP20GM103506 · NIGMS · DARTMOUTH COLLEGE · PI STEVEN FIERING · 2012 to 2026
$60.1MTLR-TRIF mediated induction of GLI3 modulates innate inflammatory responsesP20GM113131 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI Sean Stoddart Coleman Edington · 2017 to 2026
$22.8MNIGMS NIH HHS P20 GM103506NIGMS NIH HHS P20 GM113131
6 · The paper itselfAbstract
Protein arginine methyltransferase 5 (PRMT5) is a key regulator of gene expression and RNA splicing, with therapeutic potential demonstrated in MTAP-deleted cancers. Emerging evidence suggests that
Indexed as
Carcinoma, Merkel CellProtein-Arginine N-MethyltransferasesRNA SplicingAdenosineCell Line, TumorDNA-Binding ProteinsDNA HelicasesExonsHEK293 CellsHeterogeneous-Nuclear RibonucleoproteinsHumansIntronsLysine Acetyltransferase 5Merkel cell polyomavirusMultiprotein ComplexesProto-Oncogene Proteins c-mycAdenosineDNA-Binding ProteinsDNA HelicasesEP400 protein, humanHeterogeneous-Nuclear RibonucleoproteinsKAT5 protein, humanLysine Acetyltransferase 5Multiprotein ComplexesMYCL protein, humanN-methyladenosinePRMT5 protein, humanProtein-Arginine N-MethyltransferasesProto-Oncogene Proteins c-mycRNA Splice SitesSerine-Arginine Splicing FactorsSRSF1 protein, human
Identifiers
PMID40846633
PMCPMC12373721
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