Evidence map›Paper›PMID 40846526›Full record

ArticleJournal of cardiovascular computed tomography

Cardiac CT fractal analysis of LV noncompaction and common cardiomyopathies.

Ashish Manohar, Ashley Wong, Edgard Castillo, Allison Gunderson, Gabriel Mistelbauer, Shadi Peighambari Bagherzadeh, Francois Haddad, Kadir Caliskan, Ricardo P J Budde, Alexander Hirsch and 8 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular computed tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ashish ManoharDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA; Department of Radiology, Stanford University, Stanford, CA, USA; Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Ashley WongDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
Edgard CastilloCardiovascular Institute, Stanford University, Stanford, CA, USA; Tilman J. Fertitta Family College of Medicine, University of Houston, Houston, TX, USA.
Allison GundersonCardiovascular Institute, Stanford University, Stanford, CA, USA; School of Medicine, University of Nevada Reno, Reno, NV, USA.
Gabriel MistelbauerDepartment of Radiology, Stanford University, Stanford, CA, USA.
Shadi Peighambari BagherzadehDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
Francois HaddadDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA; Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Kadir CaliskanDepartment of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Ricardo P J BuddeDepartment of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Alexander HirschDepartment of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Seung-Pyo LeeDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Whal LeeDepartment of Radiology, Seoul National University Hospital, Seoul, South Korea.
Anjali OwensDepartment of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, PA, USA.
Harold LittDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Matthew WheelerDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
Deborah H KwonDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
W H Wilson TangDepartment of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Koen NiemanDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA; Department of Radiology, Stanford University, Stanford, CA, USA; Cardiovascular Institute, Stanford University, Stanford, CA, USA. Electronic address: knieman@stanford.edu.

Funding

International Consortium for Multimodality Phenotyping in Adults with Non-compactionR01HL146754 · NHLBI · STANFORD UNIVERSITY · PI NIEMAN, KOEN, TANG, WAI HONG WILSON · 2020 to 2023
$3.0M
Stanford Cardiovascular Summer Research Training Program for Medical StudentsT35HL160496 · NHLBI · STANFORD UNIVERSITY · PI America Facundo, Joseph C. Wu · 2022 to 2026
$574k
American Heart Association-American Stroke Association 24POST1187968NHLBI NIH HHS R01 HL146754NHLBI NIH HHS T35 HL160496
6 · The paper itself

Abstract

backgroundLeft ventricular noncompaction (LVNC), or hypertrabeculation, is a myocardial condition that remains challenging to diagnose and differentiate from other cardiomyopathies. This study evaluated the ability of cardiac CT to differentiate between LVNC, hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and controls using fractal analysis of LV trabeculae.

methodsSubjects with LVNC, HCM, DCM, as well as controls, who underwent coronary CT angiography were included. LV trabecular structure was quantified using fractal analysis on a stack of 15 short-axis CT images. For each subject, maximum (FD

resultsThe study included 313 subjects (median age: 58.8 [48.1-68.0] years, 153 male) categorized into Control (89), LVNC (46), HCM (106), and DCM (72) cohorts. FD

conclusionsCT-derived fractal dimensions of LV trabecular structure were significantly higher in LVNC compared to control subjects, HCM, and DCM. CT-derived fractal dimensions strongly correlated with, but were higher than, those from cardiac MRI in the same subjects.

Indexed as

Cardiomyopathy, DilatedCardiomyopathy, HypertrophicComputed Tomography AngiographyCoronary AngiographyFractalsIsolated Noncompaction of the Ventricular MyocardiumMultidetector Computed TomographyRadiographic Image Interpretation, Computer-AssistedAgedCase-Control StudiesDiagnosis, DifferentialFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedCardiomyopathyCoronary CT angiographyFractal analysisHypertrabeculationLeft ventricular noncompaction

Identifiers

PMID40846526
PMCPMC12520610

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.