ArticleBMJ open2025
Effect of high-flow nasal oxygen therapy on cardiac cycle efficiency in coronary artery disease patients undergoing endoscopy: study protocol for randomised controlled trial.
Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Pressure record analysis method parameters during weaning success and failure from mechanical ventilation in prolonged ventilated patients after cardiac surgery.Journal of thoracic disease · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPatients with coronary artery disease (CAD) have diminished tolerance for gastrointestinal endoscopy procedures (upper/lower) performed under deep sedation, resulting in increased incidence rates of hypotension and myocardial ischaemia among these patients. Avoiding hypoxemia caused by deep sedation and increased oxygen consumption caused by inadequate sedation is particularly important in these patients. Based on recent data indicating that high-flow nasal oxygen therapy (HFNO) is beneficial for preventing hypoxaemia in high-risk patients, this study investigated whether HFNO can improve myocardial oxygen supply during gastrointestinal endoscopy under deep sedation. Using cardiac cycle efficiency (CCE) data from MostCare to assess myocardial oxygen supply-demand balance in patients with CAD, we tested the hypothesis that compared with standard oxygen therapy (SOT), HFNO can improve CCE in patientswith CAD during gastrointestinal endoscopy under deep sedation. METHODS AND ANALYSIS: This single-centre randomised controlled trial will compare the effects of HFNO and SOT among CAD patients during gastrointestinal endoscopy under deep sedation administered by anaesthesiologists. 90 patients will be randomly allocated in a 1:1 ratio to two parallel groups. The primary outcome will be the difference in CCE between the two groups during sedation. Secondary outcomes will include the incidence of hypotension; the occurrence of hypoxemia; brain natriuretic peptide, troponin I and lactate levels at 6-12 hours postoperation; frequency of patient agitation episodes; intraoperative adverse memory recall; need for mask ventilation or any airway intervention; duration of sedation; HFNO-related adverse events; and MostCare haemodynamic parameters other than the primary outcome. ETHICS AND DISSEMINATION: This study has been approved by the Ethics Committee of Beijing Anzhen Hospital, Capital Medical University (KS2024066), and patients will be included after providing informed consent. The results will be submitted to a peer-reviewed journal for publication. TRIAL REGISTRATION NUMBER: ChiCTR2400086887.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.