Evidence map›Paper›PMID 40845894›Full record

ReviewProgress in biomedical engineering (Bristol, England)2025

Neuroengineering approaches assessing structural and functional changes of motor descending pathways in stroke.

Jordan N Williamson, Rita Huan-Ting Peng, Joohwan Sung, Mahmood Rajabtabar Darvish, Xiaoxi Chen, Mehreen Ali, Sheng Li, Yuan Yang

Abstract readReview
In one paragraph

Review in Progress in biomedical engineering (Bristol, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jordan N WilliamsonGrainger College of Engineering, Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, United States of America.
Rita Huan-Ting PengGrainger College of Engineering, Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, United States of America.ORCID 0009-0007-6502-2891
Joohwan SungGrainger College of Engineering, Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, United States of America.ORCID 0009-0005-0615-1402
Mahmood Rajabtabar DarvishGrainger College of Engineering, Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, United States of America.ORCID 0009-0001-2103-9735
Xiaoxi ChenGrainger College of Engineering, Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, United States of America.ORCID 0009-0002-4192-6275
Mehreen AliCarle Illinois College of Medicine, Urbana, IL, United States of America.
Sheng LiDepartment of Physical Medicine and Rehabilitation, UT Health Huston McGovern Medical School, Houston, TX, United States of America.
Yuan YangGrainger College of Engineering, Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, United States of America.ORCID 0000-0003-2442-3713

Funding

Shift from Unilateral to Bilateral Sensory-Motor Connectivity in Chronic Hemiparetic StrokeR01HD109157 · NICHD · UNIVERSITY OF OKLAHOMA · PI Yuan Yang · 2022 to 2026
$1.7M
American Heart Association-American Stroke Association 932980NICHD NIH HHS R01 HD109157
6 · The paper itself

Abstract

Stroke is a leading cause of adult disability worldwide, with approximately 101 million survivors globally. Over 60% of these individuals live with from long-term, often lifelong, movement impairments that significantly hinder their ability to perform essential daily activities and maintain independence. Post-stroke movement disabilities are highly associated with structural and functional changes in motor descending pathways, particularly the corticospinal tract and other indirect motor pathways via the brainstem. For decades, neuroengineers have been working to quantitively evaluate the post-stroke changes of motor descending pathways, aiming to establish a precision prognosis and tailoring treatments to post-stroke motor impairment. However, a clear and practicable technique has not yet been established as a breakthrough to change the standard of care for current clinical practice. In this review, we outline recent progress in neuroimaging, neuromodulation, and electrophysiological approaches for assessing structural and functional changes of motor descending pathways in stroke. We also discuss their limitations and challenges, arguing the need of artificial intelligence and large multi-modal data registry for a groundbreaking advance to this important topic.

Indexed as

Pyramidal TractsStrokeHumansNeuroimagingStroke Rehabilitationcortico-muscular connectivitymotor descending pathwaysMRIstroketranscranial magnetic stimulation (TMS)

Identifiers

PMID40845894
PMCPMC12443499

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.