ArticleImmunity2025
Transcription factor BACH2 shapes tissue-resident memory T cell programs to promote HIV-1 persistence.
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Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed.
- Natural killers blast HIV reservoir landscape.Nature immunology · 2026Article
- Blastocyst-Derived Lactic Acid Regulates Uterine Epithelial Receptivity and Stromal Decidualization via the HIF1α-HO-1-Heme Metabolic Axis.Antioxidants (Basel, Switzerland) · 2026Article
- Article
- Group 2 innate lymphoid cells: Where are we 15 years out?The Journal of allergy and clinical immunology · 2026Review
- What's Hot in HIV in 2025-A Basic and Translational Science Review From IDWeek 2025.The Journal of infectious diseases · 2026Review
- A Tissue Virus Microenvironment with Activated Stress Responses Underlies Durable SIV Persistence.bioRxiv : the preprint server for biology · 2026Article
- Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control.Nature immunology · 2026Article
- Early immune responses anticipate HIV rebound and precede viral control.bioRxiv : the preprint server for biology · 2026Article
- Single-cell characterization of the gastrointestinal HIV reservoir reveals heterogeneous cellular phenotypes.The Journal of clinical investigation · 2026Article
- Cytotoxic CD4 T Cells: Dual Agents in HIV-1 Pathogenesis and Persistence.Current HIV/AIDS reports · 2026Review
- Review
- Article
- TheInternational journal of hypertension · 2026Article
- Persistent CD4Frontiers in immunology · 2026Article
- Immune signaling as a determinant of cellular identity and tissue function.Frontiers in immunology · 2026Review
- Downregulated Expression of the IL7R and BACH2 Genes Is Associated with Immune Memory Loss in Adults Vaccinated Against HBV at Birth.Current issues in molecular biology · 2025Article
- The tuberculosis-associated microenvironment promotes HIV-1 persistence by impairing CD8+ T cell-mediated viral control.bioRxiv : the preprint server for biology · 2025Article
- BACH2 promotes seeding and establishment of long-lived HIV-1 reservoir in memory CD4Cell reports. Medicine · 2025Article
- Single cell technologies and the biology of HIV-infected CD4 T-cell reservoirs.Current opinion in HIV and AIDS · 2025Review
Corrections and comments
- Update of
Authors and funding
12 authors.
Yulong WeiDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA. Electronic address: yulong.wei@yale.edu.
Haocong Katherine MaDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Michelle E WongDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Hyein BackDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.
Emmanouil PapasavvasHIV Cure and Viral Diseases Center, Wistar Institute, Philadelphia, PA 19104, USA.
Karam MounzerThe Jonathan Lax Immune Disorders Treatment Center, Philadelphia FIGHT, Philadelphia, PA 19107, USA.
Faten AberraDivision of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Ricardo MorgensternDivision of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Pablo TebasDivision of Infectious Diseases, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Liza KonnikovaDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT 06519, USA.
Luis J MontanerHIV Cure and Viral Diseases Center, Wistar Institute, Philadelphia, PA 19104, USA.
Ya-Chi HoDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA. Electronic address: ya-chi.ho@yale.edu.
Funding
BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination ImmunotherapyUM1AI164570 · NIAID · WISTAR INSTITUTE · PI Luis J Montaner, James L. Riley · 2021 to 2026
$34.7MCHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral DynamicsU54AI170856 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI WESLEY I. SUNDQUIST · 2022 to 2026
$34.4MREACH: Research Enterprise to Advance a Cure for HIVUM1AI164565 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Marina Caskey, R. Brad Jones · 2021 to 2026
$32.9MThe Y-SCORCH Data Generation Center at Yale for Single-Cell Opioid Responses in the Context of HIVUM1DA051410 · NIDA · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, KLUGER, YUVAL · 2020 to 2025
$15.3MHigh-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Project 3P01AI169768 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Ya-Chi Ho, Jonathan Li · 2022 to 2026
$10.1MM-SCORCH: Methamphetamine use disorder data generation center for Single Cell Opioid Responses in the Context of HIVU01DA053628 · NIDA · YALE UNIVERSITY · PI HO, YA-CHI, SESTAN, NENAD · 2021 to 2025
$9.5MTowards Eradication: Reducing Proviral HIV DNA with Interferon-α ImmunotherapyU01AI110434 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J · 2014 to 2017
$7.2MIndividualized HIV Curative Combination Strategy against Persistent HIV on ARTUM1AI191272 · NIAID · WISTAR INSTITUTE · PI Luis J Montaner, ROBERT F SILICIANO · 2025 to 2026
$6.9MRole of clonal expansion in HIV-1 persistenceR01AI141009 · NIAID · YALE UNIVERSITY · PI Ya-Chi Ho · 2018 to 2026
$5.3MUnderstanding HIV-1 persistence in cytotoxic CD4+ T lymphocytes at the single cell levelR01AI174863 · NIAID · YALE UNIVERSITY · PI Ya-Chi Ho · 2023 to 2026
$3.4MEnhancing Susceptibility of HIV Reservoirs to CTL Through a Discovery to Translational ApproachR01AI176601 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI R. Brad Jones, Neville Sanjana · 2023 to 2026
$3.3MA Big Data Approach to Identify Epigenetic, Transcriptomic, and Network Dynamics as Immune Dysfunction Drivers Associated with HIV Infection and Substance Use DisorderR01DA051906 · NIDA · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER · 2020 to 2024
$2.8MNIAID NIH HHS P01 AI169768NIAID NIH HHS R01 AI141009NIAID NIH HHS R01 AI174863NIAID NIH HHS R01 AI176601NIAID NIH HHS R01 AI183430NIAID NIH HHS U01 AI110434NIAID NIH HHS U54 AI170856NIAID NIH HHS UM1 AI164565NIAID NIH HHS UM1 AI164570NIAID NIH HHS UM1 AI191272NIDA NIH HHS R01 DA051906NIDA NIH HHS R33 DA047037NIDA NIH HHS U01 DA053628NIDA NIH HHS UM1 DA051410
Abstract
Tissue-resident memory T cells (Trms) are essential for mucosal immunity. We postulated that their long-lived tissue residency and restricted effector function promoted HIV-1 persistence in the gut. We coupled single-cell DOGMA-seq and TREK-seq to capture chromatin accessibility, transcriptome, surface proteins, T cell receptors (TCRs), HIV-1 DNA, and HIV-1 RNA in gut CD4
Indexed as
Basic-Leucine Zipper Transcription FactorsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHIV-1HIV InfectionsImmunologic MemoryMemory T CellsHumansImmunity, MucosalBACH2 protein, humanBasic-Leucine Zipper Transcription FactorsBACH2gutHIV-1 reservoirHIV-1-specific CD8(+) T cellsHIV curemucosal immunitysingle-cell multi-omicsT cell clonal expansionT cell homeostasistissue-resident memory T cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.