ArticleCell reports. Medicine2025
BACH2 promotes seeding and establishment of long-lived HIV-1 reservoir in memory CD4
Abstract read
In one paragraph
Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Preparation, Oral SNEDDS Formulation, and In Vivo Evaluation of the HIV-1 Latency-Reversing Agent EK-16A.Molecules (Basel, Switzerland) · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Hongbo GaoDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Yuhao LiDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Ritudwhaj TiwariDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Marilia PinzoneDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Xiwen QinDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Kolin M ClarkDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Sara K NicholsonDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Tony YaoDepartment of Neurology, Washington University School of Medicine, Saint Louis, MO, USA.
Kelly RomeDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael ScaglioneDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Will BailisDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rachel M PrestiDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Irini SeretiDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Naresha SaligramaDepartment of Neurology, Washington University School of Medicine, Saint Louis, MO, USA; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO, USA.
Leyao WangDepartment of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.
Liang ShanDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address: shanliang@smart.org.cn.
Funding
Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1MStatistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6MValidation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MVanderbilt HIV Clinical Trials Unit (CTU)UM1AI069439 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David W Haas, Spyros A Kalams · 2012 to 2026
$33.1MCRISPR for CureUM1AI164568 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI Tricia Helen Burdo, Kamel Khalili · 2021 to 2026
$27.7MUnderstand the role of CARD8 inflammasome in HIV-1 infectionR01AI162203 · NIAID · WASHINGTON UNIVERSITY · PI PINZONE, MARILIA RITA · 2021 to 2025
$3.5MHarnessing the CARD8 Inflammasome for HIV Reservoir EliminationR01AI176594 · NIAID · WASHINGTON UNIVERSITY · PI Marilia Rita Pinzone, Francesco Roberto Simonetti · 2023 to 2026
$3.2MNovel Strategies to Enhance Effector Cell Functions for Antibody-Mediated Clearance of HIV-1 InfectionR01AI155162 · NIAID · WASHINGTON UNIVERSITY · PI SHAN, LIANG · 2020 to 2024
$3.1MStress-modified growth signaling in dynamic nutrient environmentsR35GM138085 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Will H. Bailis · 2020 to 2026
$2.7MHIV-induced microbial alterations and inflammation in the lung of humanized miceR21AI181675 · NIAID · WASHINGTON UNIVERSITY · PI PAL, PRIYA, WANG, LEYAO · 2024 to 2025
$428kDetermining and Overcoming barriers in translating HIV-1 protease mediated activation of the CARD8 inflammasome to HIV cure researchF31AI165251 · NIAID · WASHINGTON UNIVERSITY · PI CLARK, KOLIN · 2022 to 2023
$54kNCATS NIH HHS UL1 TR002345NIAID NIH HHS F31 AI165251NIAID NIH HHS R01 AI155162NIAID NIH HHS R01 AI162203NIAID NIH HHS R01 AI176594NIAID NIH HHS R21 AI181675NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI069439NIAID NIH HHS UM1 AI106701NIAID NIH HHS UM1 AI164568NIGMS NIH HHS R35 GM138085
Abstract
Despite antiretroviral therapy, HIV-1 mainly persists in memory CD4
Indexed as
Basic-Leucine Zipper Transcription FactorsCD4-Positive T-LymphocytesHIV-1HIV InfectionsImmunologic MemoryMemory T CellsAnimalsCell DifferentiationHumansMiceMice, Inbred C57BLMice, KnockoutReceptors, CCR5Virus LatencyBACH2 protein, humanBasic-Leucine Zipper Transcription FactorsReceptors, CCR5ARTBACH2CCR5CD4(+) T cellsHIV-1humanized micememory differentiationterminal differentiationviral reservoirs
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What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.