ArticleSchizophrenia research2025
A two-year longitudinal investigation of insula subregional cortical thickness and surface area in early psychosis.
Article in Schizophrenia research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
- Update of
Authors and funding
9 authors.
Funding
Abstract
backgroundSmaller insula volume is consistently observed in psychotic disorders; however, alterations in associated cortical features-thickness and surface area-are less clear. We examined insula thickness and surface area changes in early psychosis to determine whether alterations were a) present in the early stages of psychosis, b) specific to any of the insula's three cytoarchitectural subregions (agranular, dysgranular, and granular) and c) related to behaviors impacted in psychosis.
methods63 non-affective early psychosis (EP) and 59 healthy comparison (HC) participants completed 2-4 study visits over two years. Cortical thickness and surface area was quantified via T1 MRI and segmented into three anatomic subregions: anterior (agranular), middle (dysgranular), and posterior (granular). Perceptual aberrations, cognition, and psychotic symptoms were measured; group differences and longitudinal changes were tested using linear mixed models.
resultsEP participants had lower cortical thickness in all insula subregions and thickness declined at a normative rate, compared to HC participants. Insula surface area, on the other hand, was intact in EP and also showed a normative pattern of decline over two years. No significant associations were observed between structural metrics and clinical phenotypes.
conclusionsIn early psychosis, insula cortical thickness, but not surface area, is disrupted, and demonstrates normative changes over two years. This pattern is observed for all insula subregions. These data suggest that cortical thickness of the insula is structurally impacted in schizophrenia-spectrum disorders and may be the result of abnormal neurodevelopment occurring prior to illness onset.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.