Evidence map›Paper›PMID 40845355›Full record

ArticleACS chemical neuroscience2025

An Amyloidogenic Fragment of the Spike Protein from SARS-CoV-2 Virus Stimulates the Aggregation and Toxicity of Parkinson's Disease Protein Alpha-Synuclein.

João Flavio Gemignani, Paulo Augusto Netz, Daniel Izecksohn, David Dabkiewicz, Ming-Hao Li, Adalgisa Felippe Wiecikowski, David Eliezer, Yraima Cordeiro, Cristian Follmer

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In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

João Flavio GemignaniLaboratory of Biological Chemistry of Neurodegenerative Disorders, Department of Physical Chemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-909, Brazil.
Paulo Augusto NetzInstitute of Chemistry, Federal University of Rio Grande do Sul, Porto Alegre 91501-970, Brazil.
Daniel IzecksohnLaboratory of Biological Chemistry of Neurodegenerative Disorders, Department of Physical Chemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-909, Brazil.
David DabkiewiczLaboratory of Biological Chemistry of Neurodegenerative Disorders, Department of Physical Chemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-909, Brazil.
Ming-Hao LiDepartment of Biochemistry, Weill Cornell Medical College, New York, New York 10065, United States.
Adalgisa Felippe WiecikowskiFaculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
David EliezerDepartment of Biochemistry, Weill Cornell Medical College, New York, New York 10065, United States.ORCID 0000-0002-1311-7537
Yraima CordeiroFaculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Cristian FollmerLaboratory of Biological Chemistry of Neurodegenerative Disorders, Department of Physical Chemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-909, Brazil.ORCID 0000-0001-6178-0432

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence suggests that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may have long-term deleterious effects on the central nervous system and even contribute to post-COVID neurological syndromes. Interestingly, inflammation-induced proteolytic processing of the Spike protein of SARS-CoV-2 leads to the generation of peptides capable of aggregating into amyloid fibrils

Indexed as

alpha-SynucleinAmyloidParkinson DiseaseSARS-CoV-2Spike Glycoprotein, CoronavirusCell Line, TumorCOVID-19HumansPeptide FragmentsProtein AggregatesProtein Aggregation, Pathologicalalpha-SynucleinAmyloidPeptide FragmentsProtein AggregatesSNCA protein, humanSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2alpha-synucleinAlzheimer’s diseaseamyloid-betaParkinson’s diseaseSARS-CoV-2spike

Identifiers

PMID40845355
PMCPMC12412103

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.