ArticleNeurology2025
Association of Enlarged Perivascular Spaces With Early Serum and Neuroimaging Biomarkers of Alzheimer Disease Pathology.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression.Annals of neurology · 2026Article
- Plasma p-Tau217 and SPECT-Based eZIS in Mild Cognitive Impairment: Concordance Analysis with Validation in an Amyloid PET Sub-Cohort.Diagnostics (Basel, Switzerland) · 2026Article
- Associations of plasma biomarkers with longitudinal co-pathologies in Alzheimer's disease and cerebral small vessel disease comorbidity.The journal of prevention of Alzheimer's disease · 2026Article
- Neuroinflammation and blood-brain barrier dysfunction in cerebral small vessel disease: mechanisms, biomarkers, and therapeutic implications.European journal of medical research · 2026Review
- Spatial coupling of enlarged perivascular spaces and white matter lesions across the Alzheimer's disease continuum.Frontiers in neuroscience · 2026Article
- Synergistic effects of cerebral small vessel disease burden and plasma phosphorylated tau 181 on white matter microstructure and cognition in a Chinese cohort.Brain communications · 2026Article
- Association of Enlarged Perivascular Spaces With Early Serum and Neuroimaging Biomarkers of Alzheimer Disease Pathology.Neurology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesEnlarged perivascular spaces (EPVS), recognized as a key feature of cerebral small vessel disease (CSVD), have emerged as a promising biomarker for vascular contribution to Alzheimer disease (AD) and other neurodegenerative diseases. Although previous studies have linked EPVS to cerebrovascular dysfunction, their relationship with AD pathology and cognitive decline remains underexplored, particularly in multiethnic cohorts. This study investigates the associations between basal ganglia EPVS burden, blood-based biomarkers (BBM), and cognitive outcomes in a Southeast Asian cohort.
methodsThis cross-sectional study drew from the Biomarkers and Cognition Study, Singapore, comprising participants recruited from the community, at Dementia Research Centre (Singapore) from 2022 to 2024. Participants underwent comprehensive neuropsychologic assessments and were classified into cognitively normal, subjective cognitive decline, and mild cognitive impairment (MCI) groups according to established diagnostic criteria. BBM including amyloid β oligomers, amyloid β42 (Aβ42) and β40 (Aβ40), phosphorylated tau 181 (p-tau181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) were quantified. MRI Markers of CSVD (EPVS, white matter hyperintensities [WMH], lacunes, and microbleeds) were visually rated using validated scales. Associations between EPVS, biomarkers, and cognitive outcomes were analyzed using correlation or multivariable regression models adjusting for age, sex, education, cognitive diagnosis, and
resultsA total of 979 participants were included (mean age: 58.2 ± 10.7 years; mean education: 14.9 ± 3.5 years; 60.7% female). Elevated EPVS burden was positively correlated with higher GFAP (ρ = 0.166, 95% CI 0.104 to 0.228, DISCUSSION: These findings suggest EPVS burden to be a potential marker of both CSVD and AD-related BBM pathology. The results support the potential of incorporating EPVS assessments into routine MRI evaluations to enhance early detection and risk stratification in AD. Longitudinal studies are needed to confirm the prognostic value of EPVS and to clarify mechanisms linking vascular dysfunction to amyloid and tau pathology.
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