Observational studyJMIR human factors2025
Finnish Registry-Based Protocol for Screening and Management of Fatigue and Cognitive Problems in Multiple Sclerosis: Observational Study.
Observational study in JMIR human factors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Feasibility of a registry-integrated eHealth program for managing fatigue and cognitive problems in multiple sclerosis.Multiple sclerosis journal - experimental, translational and clinicalArticle
- Evaluation of patient-perceived fatigue in multiple sclerosis utilizing the Finnish MS registry.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Digital patient registries are actively used to monitor long-term diseases. However, their potential in symptom management remains underused. Objective: This study aimed to report on the Finnish registry-based protocol to screen and manage cognitive symptoms and fatigue in multiple sclerosis (MS). Data on a sample collected during the first 2 years are presented. Methods: At the beginning of 2021, a Finnish protocol to screen and manage patient-perceived concerns related to cognition and fatigue, together with self-assessment of disease severity, symptoms, and quality of life (QoL) annually, was introduced. The Symbol Digit Modalities Test (SDMT), the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ), the Fatigue Scale for Motor and Cognitive Functions (FSMC), as well as the Patient-Reported Expanded Disability Status Scale, the Visual Analog Scales, and the Euro QoL-5 Dimension were implemented into the Finnish MS registry. To support symptom management, patients were offered feedback reports based on the results of the FSMC and the MSNQ. The implementation of the protocol was evaluated in 5 Finnish wellbeing services counties. Results: Our sample from the beginning of 2021 to the end of 2022 includes data on 430 patients. A total of 86 (20%) patients have been assessed with the SDMT, whereas 329 (76.5%) patients have filled out the FSMC, and 172 (40.0%) patients have completed the MSNQ. The mean SDMT score is 49.0 (SD 13.56), MSNQ score is 35.3 (SD 9.39), total FSMC score is 63.0 (SD 22.49), and subscores for motor and cognitive fatigue are 31.6 (SD 11.43) and 31.5 (SD 11.68), respectively. The SDMT did not correlate with the MSNQ or the FSMC. Instead, the SDMT, MSNQ, and the FSMC correlated significantly with QoL. Conclusions: Fatigue and cognitive problems have an effect on QoL. In our preliminary sample, patient reports of cognitive problems and especially fatigue were conducted more frequently than the objective evaluation of processing speed. Although the Finnish MS registry offers a digital platform for the systematic screening of fatigue and cognitive problems, further education is needed to support the implementation of the protocol.
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