Evidence map›Paper›PMID 40845126›Full record

ArticleScience immunology2025

Reprogramming intratumoral T

Yujing Li, Naresh Singh, Chuanpeng Dong, Samantha Sharma, Zhuolong Zhou, Jianguang Du, Maya Haouili, Yile Jiao, Emily Hopewell, Yunlong Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yujing LiDepartment of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China.ORCID 0000-0002-3223-769X
Naresh SinghDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-4051-4084
Chuanpeng DongDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-5068-0495
Samantha SharmaDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-9599-4455
Zhuolong ZhouDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Jianguang DuHerman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-4632-6212
Maya HaouiliHerman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-3635-464X
Yile JiaoDepartment of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China.
Emily HopewellDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-4725-2531
Yunlong LiuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2699-626X
Mateusz OpyrchalMelvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-2454-7441
Xinna ZhangDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-4118-2245
Baohua ZhouHerman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-1156-4517
Xiongbin LuDepartment of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China.ORCID 0000-0002-7987-9825

Funding

Targeting FOXP3 mRNA splicing for breast cancer immunotherapyR01CA282917 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI Mateusz Opyrchal, BAOHUA ZHOU · 2023 to 2026
$2.3M
NCI NIH HHS R01 CA282917
6 · The paper itself

Abstract

Regulatory T cells (T

Indexed as

Forkhead Transcription FactorsImmunotherapyMorpholinosT-Lymphocytes, RegulatoryTriple Negative Breast NeoplasmsAnimalsCell Line, TumorFemaleHumansLymphocytes, Tumor-InfiltratingMiceMice, Inbred C57BLForkhead Transcription FactorsFOXP3 protein, humanFoxp3 protein, mouseMorpholinos

Identifiers

PMID40845126
PMCPMC13007656

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.