Evidence map›Paper›PMID 40845117›Full record

ArticleScience advances2025

Distinctive molecular features of radiation-induced thyroid cancers.

Danielle M Karyadi, Tetiana I Bogdanova, Cato M Milder, Stephen W Hartley, Olivia W Lee, Michael Dean, Vladimir Drozdovitch, Elizabeth K Cahoon, Sergii Masiuk, Mykola Chepurny and 9 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Danielle M KaryadiLaboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-4164-5625
Tetiana I BogdanovaLaboratory of Morphology of the Endocrine System, V.P. Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.ORCID 0000-0001-5119-0236
Cato M MilderRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-9400-2095
Stephen W HartleyLaboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6584-005X
Olivia W LeeLaboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5389-6267
Michael DeanLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-2234-0631
Vladimir DrozdovitchRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7952-379X
Elizabeth K CahoonRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8028-0588
Sergii MasiukRadiological Protection Laboratory, State Institution National Research Center for Radiation Medicine Hematology and Oncology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.ORCID 0000-0002-5123-9674
Mykola ChepurnyRadiological Protection Laboratory, State Institution National Research Center for Radiation Medicine Hematology and Oncology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.ORCID 0000-0001-9852-0669
Liudmyla Yu ZurnadzhyLaboratory of Morphology of the Endocrine System, V.P. Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.ORCID 0000-0001-5138-4532
Vibha VijRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-1411-0257
Cari M KitaharaRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6416-4432
Gerry A ThomasDepartment of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London, UK.
Gayle E WoloschakFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Dale A RamsdenDepartment of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-1575-4748
Mykola D TronkoDepartment of Fundamental and Applied Problems of Endocrinology, V.P. Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.ORCID 0000-0001-7421-0981
Stephen J ChanockLaboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2324-3393
Lindsay M MortonRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9767-2310

Funding

Structural determinants of Pol theta functionP01CA247773 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DALE A RAMSDEN · 2020 to 2026
$15.2M
The Role of DNA Synthesis in Nonhomologous End JoiningR01CA097096 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DALE A RAMSDEN · 2003 to 2026
$5.5M
NCI NIH HHS P01 CA247773NCI NIH HHS R01 CA097096
6 · The paper itself

Abstract

Papillary thyroid carcinoma (PTC) incidence increased after childhood exposure to radioactive fallout from the Chornobyl accident. We investigated PTC genomic profiles to distinguish radiation-induced versus sporadic oncogenic drivers by modeling dose and molecular characteristics by driver category:

Indexed as

Neoplasms, Radiation-InducedThyroid Cancer, PapillaryThyroid NeoplasmsAdolescentAdultChildFemaleHumansMaleMiddle AgedMutationProto-Oncogene Proteins B-rafProto-Oncogene Proteins B-raf

Identifiers

PMID40845117
PMCPMC12372901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.